Pharmacokinetics of intravenous dexmedetomidine in children under 11 yr of age S. Vilo, P. Rautiainen, K. Kaisti, R. Aantaa, M. Scheinin, T. Manner, K.T.

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Presentation transcript:

Pharmacokinetics of intravenous dexmedetomidine in children under 11 yr of age S. Vilo, P. Rautiainen, K. Kaisti, R. Aantaa, M. Scheinin, T. Manner, K.T. Olkkola British Journal of Anaesthesia Volume 100, Issue 5, Pages 697-700 (May 2008) DOI: 10.1093/bja/aen070 Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 1 Mean (sd) plasma concentrations of dexmedetomidine after an i.v. dose of 1 μg kg−1 in children younger or older than 2 yr of age. British Journal of Anaesthesia 2008 100, 697-700DOI: (10.1093/bja/aen070) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 2 Total plasma clearance (CL), volume of distribution at steady state (Vss), and elimination half-life (t1/2,z) of dexmedetomidine related to age. The line describes the linear regression equation between Vss and subject age. British Journal of Anaesthesia 2008 100, 697-700DOI: (10.1093/bja/aen070) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions