Accuracy of FISH analysis in predicting chromosomal status in patients undergoing preimplantation genetic diagnosis  Catherine M. DeUgarte, M.D., Man Li, M.D., Ph.D., Mark Surrey, M.D., Hal Danzer, M.D., David Hill, Ph.D., Alan H. DeCherney, M.D.  Fertility and Sterility  Volume 90, Issue 4, Pages 1049-1054 (October 2008) DOI: 10.1016/j.fertnstert.2007.07.1337 Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

Figure 1 (A) Diagram of methods. (B) Embryos evaluated for the study and the number of embryos in each category. Fertility and Sterility 2008 90, 1049-1054DOI: (10.1016/j.fertnstert.2007.07.1337) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

Figure 2 (A) Embryo on day 3, blastomere analysis done for 18, X, and Y. Reading was 1818X, Turner syndrome (two aqua signals and one red or yellow signal that appears orange after picture is taken). (B) Same embryo on day 6, a blastocyst, after fixation and FISH analysis. Of the 60 nuclei, 55 were normal female (each with two red or yellow signals and two aqua signals) and 5 were Turner syndrome. Looking back on the day 3 image, the X signals appear close together. Fertility and Sterility 2008 90, 1049-1054DOI: (10.1016/j.fertnstert.2007.07.1337) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions