Oral follicle-stimulating hormone agonist tested in healthy young women of reproductive age failed to demonstrate effect on follicular development but.

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Presentation transcript:

Oral follicle-stimulating hormone agonist tested in healthy young women of reproductive age failed to demonstrate effect on follicular development but affected thyroid function  Mireille G.F. Gerrits, Pharm.D., Hester Kramer, Ph.D., Rachid el Galta, Ph.D., Geertje van Beerendonk, Ph.D., Rob Hanssen, Ph.D., Khalid Abd-Elaziz, M.D., Christine Klipping, M.D., Ph.D., Ingrid Duijkers, M.D., Ph.D., S. Aubrey Stoch, M.D.  Fertility and Sterility  Volume 105, Issue 4, Pages 1056-1062.e4 (April 2016) DOI: 10.1016/j.fertnstert.2015.12.017 Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Treatment schedule. Fertility and Sterility 2016 105, 1056-1062.e4DOI: (10.1016/j.fertnstert.2015.12.017) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 1 Mean plasma concentration–time curves on day 1 (linear scale). Fertility and Sterility 2016 105, 1056-1062.e4DOI: (10.1016/j.fertnstert.2015.12.017) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 2 Mean plasma concentration–time curves on days 1–35 (logarithmic scale). Fertility and Sterility 2016 105, 1056-1062.e4DOI: (10.1016/j.fertnstert.2015.12.017) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 3 Structural formula of MK-8389. Fertility and Sterility 2016 105, 1056-1062.e4DOI: (10.1016/j.fertnstert.2015.12.017) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

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