Ronald A. Bronicki, MD, Carl L. Backer, MD, Harris P

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Presentation transcript:

Dexamethasone reduces the inflammatory response to cardiopulmonary bypass in children Ronald A. Bronicki, MD, Carl L. Backer, MD, Harris P. Baden, MD, Constantine Mavroudis, MD, Susan E. Crawford, MD, Thomas P. Green, MD The Annals of Thoracic Surgery Volume 69, Issue 5, Pages 1490-1495 (May 2000) DOI: 10.1016/S0003-4975(00)01082-1

Fig 1 Mean levels of complement component C3a (± standard deviation) for each sample time. Normal C3a levels are less than 400 ng/mL. There were no sample times that were significantly different between the two groups. The Annals of Thoracic Surgery 2000 69, 1490-1495DOI: (10.1016/S0003-4975(00)01082-1)

Fig 2 Mean tumor necrosis factor-α (TNF-α) levels (± standard deviation) for each sample time. Normal TNF-α levels are lower than 16 pg/mL. For sample 6 (2 minutes after cardiopulmonary bypass and prior to modified ultrafiltration), group I had a significantly lower level than group II (p = 0.03). At sample time 7, although the group II level was more than three times higher than that of group I, this did not reach significance because of the large standard deviation. The Annals of Thoracic Surgery 2000 69, 1490-1495DOI: (10.1016/S0003-4975(00)01082-1)

Fig 3 Mean levels of interleukin-6 (IL-6) (pg/mL) (± standard deviation) for each sample time. Normal IL-6 levels are less than 12 pg/mL. For sample 7 (10 minutes after protamine administration), the level in group I was significantly lower than that in group II (p = 0.03). The Annals of Thoracic Surgery 2000 69, 1490-1495DOI: (10.1016/S0003-4975(00)01082-1)

Fig 4 Mean absolute neutrophil count (× 103 cells/mL) (± standard deviation) for samples 2, 3, 5, and 8. There were no sample times that were significantly different between the two groups. The Annals of Thoracic Surgery 2000 69, 1490-1495DOI: (10.1016/S0003-4975(00)01082-1)