Orhan Bukulmez, M. D. , Bruce R. Carr, M. D. , Kathleen M. Doody, M. D

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Serum cetrorelix concentrations do not affect clinical pregnancy outcome in assisted reproduction  Orhan Bukulmez, M.D., Bruce R. Carr, M.D., Kathleen M. Doody, M.D., Kevin J. Doody, M.D.  Fertility and Sterility  Volume 89, Issue 1, Pages 74-83 (January 2008) DOI: 10.1016/j.fertnstert.2007.02.017 Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

Figure 1 The cetrorelix acetate/microdose hCG protocol used in the controlled ovarian hyperstimulation of the study population (modified and reprinted from an article in Reproductive BioMedicine Online by Bukulmez et al., 2006, with permission from Reproductive Healthcare Ltd.). Fertility and Sterility 2008 89, 74-83DOI: (10.1016/j.fertnstert.2007.02.017) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Scatter plot and linear regression line of serum cetrorelix levels by percent change between pre- and post-hCG serum estradiol levels. Patients with and without clinical pregnancies are depicted with different symbols. There is no correlation between serum cetrorelix levels and percent serum estradiol change pre- versus post-hCG administration (r = 0.15, P=.117). Fertility and Sterility 2008 89, 74-83DOI: (10.1016/j.fertnstert.2007.02.017) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

Figure 3 Box and whisker plots of serum cetrorelix levels (ng/mL) by implantation rate category (P=.45). Box represents the middle 50% of the data, while median is the horizontal line in the box. The whiskers extend above and below the 75th and 25th percentiles. Values above whiskers are outliers. Three times the box width marks the boundary between “mild” (dot) and “extreme” (stars) outliers. Fertility and Sterility 2008 89, 74-83DOI: (10.1016/j.fertnstert.2007.02.017) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions