Volume 57, Issue 5, Pages (May 2000)

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Volume 57, Issue 5, Pages 1962-1967 (May 2000) Proximal tubular epithelial hyperplasia in patients with chronic glomerular proteinuria Lee A. Hebert, Garima Agarwal, Daniel D. Sedmak, John D. Mahan, William Becker, Haikady N. Nagaraja Kidney International Volume 57, Issue 5, Pages 1962-1967 (May 2000) DOI: 10.1046/j.1523-1755.2000.00045.x Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 1 Photomicrographs of renal tubular cross-sections from the first (A) and the second (B–D) renal biopsies from patient CHAL. The first biopsy (A) shows evidence of tubular injury (loss of proximal tubular brush border and cytoplasm, and hypocellularity). By contrast, the second biopsy (B–D) shows multiple tubules with epithelial hyperplasia, focal crowding, and piling up of cells. In addition, many cells show an increased nuclear to cytoplasmic ratio and focal mild nuclear pleomorphism (PAS, original magnification ×100). Kidney International 2000 57, 1962-1967DOI: (10.1046/j.1523-1755.2000.00045.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 2 Mean number of proximal tubular epithelial cell nuclei/proximal tubular cross-section (mean nuc/PTCS) in group A first biopsy (A-Bx1) and second biopsy (A-Bx2) and in group B (B). Group A-Bx1 and Bx2 results are compared by pairedt-test. Group A-Bx2 and group B results are compared by the Wilcoxon rank sum test. The mean ± SE is shown for each group by the solid circle and bars. The values shown are the mean number of counts in each of the 20 fields examined. The lines drawn between data points for group A patients indicate values from the same individual. Kidney International 2000 57, 1962-1967DOI: (10.1046/j.1523-1755.2000.00045.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 3 Proximal tubular volume (PTV) in group A and group B patients. Group A-Bx1 and Bx2 results are compared by pairedt-test. Group A-Bx2 and group B are compared by Wilcoxon rank sum test. The mean ± SE is shown for each group by the solid circle and bars. The lines drawn between data points for group A patients indicate values from the same individual. Kidney International 2000 57, 1962-1967DOI: (10.1046/j.1523-1755.2000.00045.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 4 Ratio of the mean number of proximal tubular epithelial cell nuclei/tubular cross-section (mean nuc/PTCS)/mean relative proximal tubular volume (PTV) in group A and group B patients. Group A-Bx1 and group A-Bx2 are compared by pairedt-test. Group A-Bx2 and group B results are compared by Wilcoxon rank sum test. The mean ± SE is shown for each group by the solid circle and bars. The lines drawn between data points for group A patients indicate values from the same individual. Kidney International 2000 57, 1962-1967DOI: (10.1046/j.1523-1755.2000.00045.x) Copyright © 2000 International Society of Nephrology Terms and Conditions