Renal phenotype of low kallikrein rats

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Renal phenotype of low kallikrein rats Paolo Madeddu, Carlos P. Vio, Stefania Straino, Maria Bonaria Salis, Anna Franca Milia, Costanza Emanueli Kidney International Volume 59, Issue 6, Pages 2233-2242 (June 2001) DOI: 10.1046/j.1523-1755.2001.00738.x Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 1 Kallikrein activity in tissue homogenates of normal Wistar rats (□) and low kallikrein rats (LKR; ▪). Kallikrein activity was reduced in kidney and was increased in heart of LKR. Data are means ± SEM (N = 6). +P < 0.05 vs. Wistar rats. Kidney International 2001 59, 2233-2242DOI: (10.1046/j.1523-1755.2001.00738.x) Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 2 Histologic sections of kidneys from Wistar rat and low kallikrein rat (LKR), stained with antibody against rat kallikrein (×120 magnifications). Control Wistar rat (B) illustrating typical normal staining of distal tubular cells positive for kallikrein (arrow). (A) LKRs illustrating the faint staining of tubular cells (arrow); tubular dilation is also shown. Kidney International 2001 59, 2233-2242DOI: (10.1046/j.1523-1755.2001.00738.x) Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 3 Urinary kallikrein activity in normal Wistar rats (A) and LKR (B) under basal conditions (□) and after gentamycin (▪) or vehicle (). Gentamycin administration reduced urinary kallikrein in both strains. Data are means ± SEM (N = 6 each group). +P < 0.05 vs. basal. Kidney International 2001 59, 2233-2242DOI: (10.1046/j.1523-1755.2001.00738.x) Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 4 Effect of angiotensin II subtype 1 (AT1) receptor blockade on renal function in normal Wistar rats (○) or LKR (•). LKR showed polydipsia, polyuria, glomerular hyperfiltration, and increased enzymuria under basal conditions, with these alterations being partially corrected by AT1 receptor blockade. In addition, fractional sodium excretion was increased by AT1 receptor blockade in LKRs (data shown in the Results section). Data are means ± SEM (N = 6 each group). +P < 0.05 vs. control; §P < 0.05 vs. basal. Kidney International 2001 59, 2233-2242DOI: (10.1046/j.1523-1755.2001.00738.x) Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 5 Effect of acute AT1 receptor blockade (A–C) or intravenous volume loading (D–F) on systemic and renal hemodynamics in normal Wistar rats (•) or LKR (○). For the AT1 blockade, LKRs showed a greater reduction in mean blood pressure (MBP) and a more rapid renal vasodilation compared with controls (N = 10 each group). For volume loading, LKR exhibited blunted systemic and renal vasodilatory response compared with controls (N = 7 each group). Data are means ± SEM. +P < 0.05 vs. control; §P < 0.05 vs. basal. Kidney International 2001 59, 2233-2242DOI: (10.1046/j.1523-1755.2001.00738.x) Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 6 Effects of water deprivation on UV (A) and osmolality (B) in normal Wistar rats (○) or LKR (•). Water deprivation revealed intact urinary concentrating mechanisms in LKR. Data are means ± SEM. +P < 0.05 vs. control; §P < 0.05 vs. basal. Kidney International 2001 59, 2233-2242DOI: (10.1046/j.1523-1755.2001.00738.x) Copyright © 2001 International Society of Nephrology Terms and Conditions