Nasal AMP and histamine challenge within and outside the pollen season in patients with seasonal allergic rhinitis Sriram Vaidyanathan, MBBS, Peter Williamson,

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Presentation transcript:

Nasal AMP and histamine challenge within and outside the pollen season in patients with seasonal allergic rhinitis Sriram Vaidyanathan, MBBS, Peter Williamson, MBChB, Karine Clearie, MBChB, Ashley Morrison, MSc, Brian Lipworth, MD Journal of Allergy and Clinical Immunology Volume 127, Issue 1, Pages 173-178.e3 (January 2011) DOI: 10.1016/j.jaci.2010.09.006 Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Recovery profile over 60 minutes for percentage PNIF change after nasal AMP and nasal histamine challenge. The asterisk (∗) denotes a significant difference (P < .05) between preseason and in-season time-profile averaged values. The postseason time-profile curve for recovery for nasal AMP did not improve to preseason values (P < .05) and is denoted by a dagger (†). Journal of Allergy and Clinical Immunology 2011 127, 173-178.e3DOI: (10.1016/j.jaci.2010.09.006) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Scatter plots showing PC30 and PC60 values during AMP and histamine nasal challenges. The y-axis is a logarithmic scale, and geometric means with 95% CIs are displayed. There was a significant decrease in AMP PC30, but not histamine PC30, during the pollen season. Journal of Allergy and Clinical Immunology 2011 127, 173-178.e3DOI: (10.1016/j.jaci.2010.09.006) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Scatter plots showing individual values for domiciliary PNIF rates and TNSSs before, during, and after the pollen season. Horizontal lines and error bars represent arithmetic means and SEMs, respectively. There is a decrease (P < .05) in PNIF rate and an increase (P < .05) in nasal symptoms during the pollen season. Journal of Allergy and Clinical Immunology 2011 127, 173-178.e3DOI: (10.1016/j.jaci.2010.09.006) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions