Coregulation of VGAT and cGMP levels by dopamine.

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Coregulation of VGAT and cGMP levels by dopamine. Coregulation of VGAT and cGMP levels by dopamine. (A) Dopaminergic lesion paradigm. Mice received a unilateral injection of either 6-hydroxydopamine (OHDA) or vehicle to the medial forebrain bundle and daily intraperitoneal injections of benseazide (15 mg/kg) with l-dopa (6 mg/kg, LD) or saline (sal). (B) VGAT and DARPP-32 immunolabeling in the striatum after dopaminergic lesion. Representative images from ipsilateral (ipsi.) and contralateral (cont.) striatum of a mouse treated with 6-hydroxydopamine and saline. Note in the magnified images that VGAT labeling (shown in yellow in the image from the contralateral) is reduced in the soma of SPNs of the ipsilateral striatum (appears green). (Scale bar: 20 µm.) (C) Bar graph summary of ratios of VGAT and DARPP-32 mean pixel values (n = 5–6 mice per group, seven slices per mouse). Bars represent mean ratios in the ipsilateral striatum as percentage of that in the contralateral ± SD. (D) cGMP levels. Bars represent cGMP level in the ipsilateral striatum normalized to tissue wet weight, as percentage of the contralateral ± SD (n = 4–5 mice per group). (E) For each treatment group, the mean cGMP level is plotted against the mean of VGAT labeling ratio. Yotam Sagi et al. PNAS 2014;111:49:17636-17641 ©2014 by National Academy of Sciences