Sebastiano Sciarretta et al. JACC 2018;71:

Slides:

Advertisements

Similar presentations

Date of download: 6/9/2016 Copyright © The American College of Cardiology. All rights reserved. From: Cardiomyocyte-Specific Deletion of Gsk3α Mitigates.

Advertisements

Date of download: 6/23/2016 Copyright © The American College of Cardiology. All rights reserved. From: 17-Beta-Estradiol increases cardiac remodeling and.

Date of download: 9/19/2016 Copyright © The American College of Cardiology. All rights reserved. From: Exenatide Reduces Infarct Size and Improves Cardiac.

Fig. 3. Effect of JGH43IA on the glutamate-induced DNA fragmentation

Journal of Molecular and Cellular Cardiology

Transforming Growth Factor‐β Receptor III is a Potential Regulator of Ischemia‐Induced Cardiomyocyte Apoptosis by Fei Sun, Xin Li, Wen‐Qi Duan, Wei Tian,

Activation of Liver-X-Receptor α But Not Liver-X-Receptor β Protects Against Myocardial Ischemia/Reperfusion InjuryCLINICAL PERSPECTIVE by Qing He, Jun.

Kenichi Fujii et al. JIMG 2015;8:

The absence of Yca1 attenuates the apoptotic phenotypes of lsm4 mutants. The absence of Yca1 attenuates the apoptotic phenotypes of lsm4 mutants. (A) Wild‐type.

Bindiya Patel et al. BTS 2018;3:

A Topical Mitochondria-Targeted Redox-Cycling Nitroxide Mitigates Oxidative Stress- Induced Skin Damage Rhonda M. Brand, Michael W. Epperly, J. Mark Stottlemyer,

Steven E. Williams et al. JACEP 2015;1:

Volume 79, Issue 2, Pages (January 2011)

Abnormally enhanced cystic fibrosis transmembrane conductance regulator-mediated apoptosis in endometrial cells contributes to impaired embryo implantation.

High basal level of autophagy in high-altitude residents attenuates myocardial ischemia– reperfusion injury Yijie Hu, MD, Qi Sun, MD, Zhiping Li, MD,

by Simon F. De Meyer, Alexander S. Savchenko, Michael S

Molecular Therapy - Nucleic Acids

Dean J. Kereiakes et al. JACC 2017;70:

Carolyn Y. Ho et al. JCHF 2015;3:

Meena Nathan, MD, Ingeborg Friehs, MD, Yeong-Hoon Choi, MD, Douglas B

Volume 88, Issue 3, Pages (September 2015)

N-acetylcysteine improves function and follicular survival in mice ovarian grafts through inhibition of oxidative stress Monireh Mahmoodi, Malek Soleimani.

Volume 84, Issue 5, Pages (November 2013)

A novel vascularized patch enhances cell survival and modifies ventricular remodeling in a rat myocardial infarction model Qi Zhou, MD, PhD, Jian-Ye.

Stat3 promotes lung fibrosis and collagen synthesis independent of Smad3.A.Masson's trichrome stained sections of lung from gp130wt (wt), Smad3−/− (Smad3−/−),

Inhaled nitric oxide attenuates apoptosis in ischemia-reperfusion injury of the rabbit lung Hideki Yamashita, MD, Shinji Akamine, MD, Yorihisa Sumida,

Endothelin A receptor blockade improves regression of flow-induced pulmonary vasculopathy in piglets Olaf Mercier, MD, Edouard Sage, MD, Mohammed Izziki,

Inhibition of MicroRNA-204 Conducts Neuroprotection Against Spinal Cord Ischemia Lihui Yan, MD, Enyi Shi, MD, PhD, Xiaojing Jiang, MD, PhD, Jiang Shi,

Eran Leshem et al. JACEP 2017;j.jacep

Bindiya Patel et al. BTS 2018;j.jacbts

Cardiac Fibrosis at 18 Weeks Post TAC (A) Representative images (original magnification ×20) of Picrosirius red-stained cardiac tissue sections from HF +

Hironori Hara et al. BTS 2018;3:

Regression of flow-induced pulmonary arterial vasculopathy after flow correction in piglets Olaf Mercier, MD, Edouard Sage, MD, Marc de Perrot, MD, Ly.

Elysse C. Filipe et al. BTS 2018;3:38-53

Brian R. Weil et al. BTS 2017;2: Experimental Protocol (A) Following baseline data collection, the left anterior descending coronary artery was.

Mintu P. Turakhia et al. JACEP 2016;2:

Renal Fibrosis and Plasma Creatinine Levels at 18 Weeks Post TAC (A) Plasma creatinine levels. (B) Representative images (original magnification ×20) of.

Isaac Perea-Gil et al. BTS 2016;1:

Volume 88, Issue 4, Pages (October 2015)

Obesity aggravates tumor desmoplasia.

Volume 19, Issue 4, Pages (April 2011)

NRP1-expressing myeloid cells influence adipocyte hypertrophy, development of fatty liver, and CLSs. NRP1-expressing myeloid cells influence adipocyte.

Fig. 6 Combination therapy with LVSOD2 and LVshCTGF preserves flap volume and reduces fibrosis after RT. Combination therapy with LVSOD2 and LVshCTGF preserves.

ILK knockdown decreases mTOR signaling in PKD kidneys.

Sebastiano Sciarretta et al. JACC 2018;71:

Tapetal mitochondria in wild-type (WT), drp3b, and elm1 mutants.

Limiting neutrophilic inflammation during active phase (ZT13) reduces MI damage Limiting neutrophilic inflammation during active phase (ZT13) reduces MI.

Tomoregulin-1 improves cardiac pathological changes after pressure overload. Tomoregulin-1 improves cardiac pathological changes after pressure overload.

Expression of tomoregulin-1 in wild-type and cardiac hypertrophy mouse myocardium. Expression of tomoregulin-1 in wild-type and cardiac hypertrophy mouse.

Characterization of zebrafish muscle wasting in krasG12V-induced HCC zebrafish. 4-month-old male adult krasG12V and WT zebrafish were treated with dox.

SW fraction induces S phase arrest and apoptosis.

Fig. 4. Deletion of Baf60c in myocardium results in dilated chambers and impaired cardiac function. Deletion of Baf60c in myocardium results in dilated.

The absence of host Fbln5 results in increased apoptosis and decreased proliferation in Pan02 tumors. The absence of host Fbln5 results in increased apoptosis.

Urinary albumin excretion and histology of glomeruli.

Apoptosis in CAM vessels after staining with TUNEL

A: Representative sections from the LV of sham and diabetic Ntg and IGF-1R mice. A: Representative sections from the LV of sham and diabetic Ntg and IGF-1R.

IKKβ protects adipocytes from HFD-induced cell death.

Fig. 1 Neu1−/− fibroblasts have characteristics of myofibroblasts.

Fig. 1. DEL-1 is expressed by human and mouse osteoclasts.

Maxime Berthelot-Richer et al. JIMG 2016;9:

Mackram F. Eleid et al. JIMG 2016;9:

Fig. 6. Prolonged miR overexpression in the adult heart reduces fibrotic scar size but compromises cardiac function after MI. Prolonged miR

Mackram F. Eleid et al. JIMG 2016;9:

Treg expression of Gata3 plays a major role in controlling dermal fibrosis. Treg expression of Gata3 plays a major role in controlling dermal fibrosis.

Chronic Treg reduction results in dermal fibrosis.

Pomalidomide decreases fibrosis in the lesion areas of the pancreas of KC mice. Pomalidomide decreases fibrosis in the lesion areas of the pancreas of.

N1 decoys reduced perfusion and JAG-specific decoys disrupted pericyte association in Mm5MT-FGF4 tumors. N1 decoys reduced perfusion and JAG-specific decoys.

L-Carnitine decreases DNA damage and improves the in vitro blastocyst development rate in mouse embryos Hussein Abdelrazik, M.D., Rakesh Sharma, Ph.D.,

GCS-100 selectively kills KRAS-addicted lung tumors.

SCLC in CMV TKO mice arises from an alternative cell of origin.

Presentation transcript:

Sebastiano Sciarretta et al. JACC 2018;71:1999-2010 Beneficial Effects of Trehalose on Cardiac Apoptosis and Fibrosis in Response to LAD Ligation Are Attenuated in beclin 1+/− Mice (A to F) WT and beclin 1+/− mice with LAD ligation received CT or TRE. (A) After 4 weeks, infarct size was measured. (B) Representative pictures of Masson’s trichrome staining of the whole left ventricular transverse section are also shown. Scale bar: 1 mm. (C and D) Apoptosis was evaluated by quantification of TUNEL-positive cells. Data are expressed as fold versus CT. n = 4 to 7 per group. (E) The percentage of cardiac fibrosis was also quantified, and (F) representative pictures of Masson’s trichrome staining are shown. n = 4 per group. **p < 0.01. Scale bar: 50 μm. DAPI = 4’,6-diamidino-2-phenylindole; PLA = placebo; TUNEL = terminal deoxynucleotidyl transferase dUTP nick end labeling; other abbreviations as in Figure 1. Sebastiano Sciarretta et al. JACC 2018;71:1999-2010 2018 American College of Cardiology Foundation