Glucagon potentiates intestinal reperfusion injury

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Presentation transcript:

Glucagon potentiates intestinal reperfusion injury Elizabeth T. Clark, MD, Bruce L. Gewertz, MD Journal of Vascular Surgery Volume 11, Issue 2, Pages 270-279 (February 1990) DOI: 10.1016/0741-5214(90)90270-K Copyright © 1990 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 1 Experiments were performed in denervated isoperfused rat intestinal preparations. Journal of Vascular Surgery 1990 11, 270-279DOI: (10.1016/0741-5214(90)90270-K) Copyright © 1990 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 2 Histologic grading system. Epithelial morphology of individual intestinal sections was evaluated in a blinded manner by use of a modification of the Chui system. (Original magnification × 25.) Journal of Vascular Surgery 1990 11, 270-279DOI: (10.1016/0741-5214(90)90270-K) Copyright © 1990 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 3 Effect of glucagon before ischemia on intestinal blood flow (IBF) and oxygen extraction (VO2). Journal of Vascular Surgery 1990 11, 270-279DOI: (10.1016/0741-5214(90)90270-K) Copyright © 1990 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 4 Histologic grades of experimental groups. Journal of Vascular Surgery 1990 11, 270-279DOI: (10.1016/0741-5214(90)90270-K) Copyright © 1990 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 5 Oxygen extraction (VO2) and histologic grade as related to glucagon concentration and duration of ischemia. Journal of Vascular Surgery 1990 11, 270-279DOI: (10.1016/0741-5214(90)90270-K) Copyright © 1990 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 6 Concept of an “ischemic threshold” that relates mucosal injury to both blood flow and duration of flow disturbance. Increases in ischemic mucosal injury (e.g., grades 4 and 5) require longer periods of flow interruption and may not occur if perfusion is maintained above an arbitrary limit. Journal of Vascular Surgery 1990 11, 270-279DOI: (10.1016/0741-5214(90)90270-K) Copyright © 1990 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions