Sebastiano Sciarretta et al. JACC 2018;71:

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Sebastiano Sciarretta et al. JACC 2018;71:1999-2010 Beneficial Effects of Trehalose on Cardiac Remodeling and Function in Response to LAD Ligation Are Attenuated in beclin 1+/− Mice (A to F) Wild-type (WT) and beclin 1+/− mice with LAD ligation received CT or TRE. After 4 weeks, they were subjected to echocardiographic analysis to assess (A) LVEDD and (B) FS. (C) Lung and (D) heart weight were also measured. n = 9 in placebo group; n = 11 in TRE group; n = 8 in beclin-1 +/− placebo group; n = 9 in beclin-1 +/− TRE group. Cell size was measured in left ventricular myocardial tissue sections. Quantification of (E) the cross-sectional area (CSA), together with (F) representative pictures of wheat germ agglutinin staining are shown. Data are presented as fold versus WT CT. n = 4 per group. *p < 0.05. Scale bar: 50 μm. HW = heart weight; TL = tibia length; other abbreviations as in Figure 1. Sebastiano Sciarretta et al. JACC 2018;71:1999-2010 2018 American College of Cardiology Foundation