Getting a gRIP on Flu by Casting the DAI

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Getting a gRIP on Flu by Casting the DAI Danielle M. Clancy, Seamus J. Martin Cell Host & Microbe Volume 20, Issue 5, Pages 552-554 (November 2016) DOI: 10.1016/j.chom.2016.10.013 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 DAI-Dependent RIPK1 and RIPK3-Dependent Cell Death Pathways (A) In the context of caspase inhibition, TNF signaling can promote necroptosis via RIPK1/RIPK3-dependent MLKL phosphorylation, resulting in oligomerization of the latter and rapid membrane permeabilization. (B–D) Influenza A virus (IAV) infection can result in the assembly of three distinct DAI-containing complexes, resulting in either RIPK3/RIPK1-dependent caspase-8 activation and apoptosis (B), RIPK3/MLKL-dependent necroptosis (C), or RIPK1/caspase-8-dependent apoptosis (D). Cell Host & Microbe 2016 20, 552-554DOI: (10.1016/j.chom.2016.10.013) Copyright © 2016 Elsevier Inc. Terms and Conditions