Allergens are distributed into few protein families and possess a restricted number of biochemical functions Christian Radauer, PhD, Merima Bublin, PhD,

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Presentation transcript:

Allergens are distributed into few protein families and possess a restricted number of biochemical functions Christian Radauer, PhD, Merima Bublin, PhD, Stefan Wagner, PhD, Adriano Mari, MD, Heimo Breiteneder, PhD Journal of Allergy and Clinical Immunology Volume 121, Issue 4, Pages 847-852.e7 (April 2008) DOI: 10.1016/j.jaci.2008.01.025 Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 The 15 protein families with the highest number of allergens classified by source (A) and route of exposure (B). Numbers in Fig 1, B, differ because of multiple or missing routes of exposure for some allergens. C, Protein family distribution of randomly selected sequences. ox., Oxidase; oxred., oxidoreductase; PD, periplasmic domain; RuBisCo. ribulose-1,5-bisphosphate carboxylase/oxidase; TD, transmembrane domain; term., terminal; NADH, nicotinamide adenine dinucleotide. Journal of Allergy and Clinical Immunology 2008 121, 847-852.e7DOI: (10.1016/j.jaci.2008.01.025) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Sequence conservation among homologous allergens. Amino acid sequences of allergens from the prolamin superfamily (A), the tropomyosin family (B), and the EF-hand superfamily (C) were aligned, and neighbor-joining phylogenetic trees were generated. Percentage sequence identities to reference allergens (bold) are encoded by gray shades. Journal of Allergy and Clinical Immunology 2008 121, 847-852.e7DOI: (10.1016/j.jaci.2008.01.025) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions