The emerging treatment paradigms for overall management of advanced SQCLC. SQCLC, squamous cell lung cancer; TPS, tumour proportion score; Pembro, pembrolizumab; Chemo-P, platinum-based chemotherapy; IO, immunotherapy; D+R, docetaxel plus ramucirumab; D, docetaxel; Nivo, nivolumab; Atezo, atezolizumab; 1st, first; 2nd, second; 3rd, third; PD-L1, programmed cell death-1 ligand. The emerging treatment paradigms for overall management of advanced SQCLC. SQCLC, squamous cell lung cancer; TPS, tumour proportion score; Pembro, pembrolizumab; Chemo-P, platinum-based chemotherapy; IO, immunotherapy; D+R, docetaxel plus ramucirumab; D, docetaxel; Nivo, nivolumab; Atezo, atezolizumab; 1st, first; 2nd, second; 3rd, third; PD-L1, programmed cell death-1 ligand. Yi-Chen Zhang et al. ESMO Open 2017;2:e000129 Copyright © European Society for Medical Oncology. All rights reserved.