Proposed model of how USP2a-driven microRNA deregulation enhances MYC protein expression through impairment of the MDM2–p53 pathway. p53 regulates miR-34b/c.

Slides:

Advertisements

Similar presentations

MDM2: Oncogene Chan Lee. Discovery of MDM2: starting with tumor suppressor p53.

Advertisements

Chapter 13  Differential Gene Expression & plant development.

Systematic identification of 3′-UTR regulatory elements in activity-dependent mRNA stability in hippocampal neurons by Jonathan E. Cohen, Philip R. Lee,

Date of download: 7/10/2016 Copyright © 2016 McGraw-Hill Education. All rights reserved. Basic steps of gene expression—transcription factors regulate.

Enhanced DNA damage in IDH1 mutant glioma cells.

a b SUM149PT Motility Invasion C V C V

IL-22 Gets to the Stem of Colorectal Cancer

miR-133a positively regulated p53/p21 pathway.

ETV1 positively regulates KIT expression through direct binding to KIT enhancers in human GIST cells and forms a positive feedback circuit in GIST oncogenesis.

MAPK pathway inhibitors.

Auxin and GA promote fruit growth by activating ABA catabolism in the early stage and are important for the regulation of interlinked regulatory loops.

Differential expression of select miRNAs was validated in a second cohort of patients. Differential expression of select miRNAs was validated in a second.

Lymphoma spread? Target CD47-SIRPα!

The Wind God Promotes Lung Cancer

Polycomb Regulates NF-κB Signaling in Cancer through miRNA

microRNAs in cancer management

Volume 10, Issue 8, Pages (March 2015)

IL32 prompts cell activation and cancer-related pathways.

Nat. Rev. Nephrol. doi: /nrneph

Schematic model of effector pathways that mediate tumor suppression by p53. Schematic model of effector pathways that mediate tumor suppression by p53.

MicroRNA Control in the Immune System: Basic Principles

Nat. Rev. Clin. Oncol. doi: /nrclinonc

MexT-associated downregulation of oprD expression.

USP2a-dependent miRs deregulation modulates MYC expression.

USP2a overexpression modifies the microRNA expression profile of prostate cells. USP2a overexpression modifies the microRNA expression profile of prostate.

Overexpression of Nedd4 is able to rescue miR-1-mediated actin fiber disarray in larval hearts. Overexpression of Nedd4 is able to rescue miR-1-mediated.

A model of signaling events regulating zebrafish fin regeneration.

Hypothetical model of HvAP2 control of stem elongation.

Marta Chesi, P. Leif Bergsagel Cancer Cell

PTK6 downregulation suppresses SNAIL and increases E-cadherin expression. PTK6 downregulation suppresses SNAIL and increases E-cadherin expression. A,

USP2a regulates MYC expression through the MDM2–p53 axis.

Figure 2 Signalling downstream of the IL-6 receptor

Model for TGF-β-induced myofibroblast differentiation involving MKL1 isoform-specific activities. Model for TGF-β-induced myofibroblast differentiation.

Mechanism of macrophage apoptosis caused by H. pylori.

Model for the regulation of HIPK2 activity and p53 phosphorylations by the ATM pathway. Model for the regulation of HIPK2 activity and p53 phosphorylations.

Regulation of p53 by MDM2. p53 and MDM2 form an autoregulatory feedback loop. p53 stimulates the expression of MDM2; MDM2, in turn, inhibits p53 activity.

Integrated mRNA and microRNA expression and DNA methylation clusters.

CXCL14-positive CAFs induce overexpression of LINC00092 in ovarian cancer. CXCL14-positive CAFs induce overexpression of LINC00092 in ovarian cancer. A,

SATB2-AS1 repressed Snail transcription depending on SATB2-mediated recruitment of HDAC1. SATB2-AS1 repressed Snail transcription depending on SATB2-mediated.

Heat map of genes for which CR significantly altered expression versus AL. Cluster analysis of genes significantly changed by the CR intervention compared.

Overexpression of miR-335, but not miR-29a, reduces in vitro carcinogenesis. Overexpression of miR-335, but not miR-29a, reduces in vitro carcinogenesis.

NOTCH1 and MYC regulate leukemia cell growth.

Schematic view of intracellular signaling cascades triggered by receptor tyrosine kinase in Schwann cells. Schematic view of intracellular signaling cascades.

Western blot analysis of Wnt signaling genes.

MiR-200c is a PI3K–AKT signaling pathway regulator in CRC

RNF2 promotes TGFβ signaling.

Activation of Wnt signaling pathway in trastuzumab-resistant cell lines. Activation of Wnt signaling pathway in trastuzumab-resistant cell lines. A, bar.

Discovered and replicated positive correlation between miR-193b

CDK6 induces a transcriptional program to antagonize p53.

Tenets of PTEN Tumor Suppression

SBC-5 miR-335+, but not SBC-5 miR-29a+, exhibited reduced IGF-IR expression. SBC-5 miR-335+, but not SBC-5 miR-29a+, exhibited reduced IGF-IR expression.

RUNX3 depletion induces cellular senescence and inflammatory cytokine expression in cells undergoing TGFβ-mediated EMT. A, Cells were transfected with.

MYC–HOXB7–HER2 predicts clinical outcome in breast cancer patients treated with tamoxifen. MYC–HOXB7–HER2 predicts clinical outcome in breast cancer patients.

One-way hierarchical cluster analysis of SAM-identified genes using the TMEV software to see the data substructure. One-way hierarchical cluster analysis.

PVT1 facilitated gastric cancer progression in a FOXM1-mediated manner

Hippo-based model. Hippo-based model. Arrows point out the direction of signaling: in orange, the YAP signaling effects on p73 driven by c-Abl, in blue.

Enhanced expression of Cap43 gene by nickel in breast cancer cell lines. Enhanced expression of Cap43 gene by nickel in breast cancer cell lines. Expression.

The critical roles of miR-23a and miR-27a in colorectal cancer progression. miR-23a primarily increases cell motility through downregulation of its target.

CTLA-4 and PD-1 modulate different aspects of the T-cell response: A, CTLA-4 is upregulated after antigen-specific activation of a naïve or memory T cell.

Fig. 4. miR promotes cardiomyocyte proliferation through regulation of Hippo pathway kinases. miR promotes cardiomyocyte proliferation through.

HOXA11-AS acts as a ceRNA for miR-1297.

HOXA9 and STAT5 co-occupy similar genomic regions and increase JAK/STAT signaling. HOXA9 and STAT5 co-occupy similar genomic regions and increase JAK/STAT.

Schematic representation of signaling pathways associated with cannabinoid receptor activation induced by its agonists. Schematic representation of signaling.

HER2 and PI3K-targeted therapies result in FOXO3a-mediated feedback upregulation of HER3 and IGF1R and provide an escape from PI3K pathway inhibition.

NF1-associated and sporadic MPNST cell lines show a decrease in cell viability, soft agar colony formation, and xenograft tumor growth when Wnt/β-catenin.

ERM proteins promote CD44 cleavage.

Schematic of models of N-MYC overexpression-driven genetically engineered mouse tumor models and human tissue recombination models. Schematic of models.

MYC is required for the hypoxic induction of SHMT2.

Skp2, the FoxO1 hunter Cancer Cell

A schematic diagram showing the mechanism by which L5 triggers platelet activation and aggregation. A schematic diagram showing the mechanism by which.

Presentation transcript:

Proposed model of how USP2a-driven microRNA deregulation enhances MYC protein expression through impairment of the MDM2–p53 pathway. p53 regulates miR-34b/c expression through promoter enhancement. Proposed model of how USP2a-driven microRNA deregulation enhances MYC protein expression through impairment of the MDM2–p53 pathway. p53 regulates miR-34b/c expression through promoter enhancement. A, when overexpressed, USP2a transcriptionally downregulates miR-34b/c with subsequent MYC activation through MDM2-mediated p53 inactivation. B, low USP2a expression triggers the upregulation of miR-34b/c with subsequent MYC deactivation through MDM2-mediated p53 activation. Barbara Benassi et al. Cancer Discovery 2012;2:236-247 ©2012 by American Association for Cancer Research