Model of translational regulation by PDGFRα.

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Model of translational regulation by PDGFRα. Model of translational regulation by PDGFRα. In comparison with acute stimulation of PDGFRα receptor, chronic stimulation results in decreased phosphorylation of RSK1/2 and S6K1/2, which subsequently impairs the phosphorylation of S6 ribosome protein and associated ribosome biogenesis and 5′ TOP mRNA translation. On the other hand, the phosphorylation of 4EBP1 and PDCD4 are suppressed, which subsequently limited the components of the eIF4F complex (eIF4E and eIF4A) from joining into the complex. In addition, the phosphorylation of the translation initiation factor eIF4B is also decreased. These changes result in a suppressed CAP-dependent translation initiation in cells with chronic stimulated PDGFRα signaling compared with acute stimulated ones. Shuang Zhou et al. LSA 2018;1:e201800029 © 2018 zhou et al.