Hereditary Isolated Renal Magnesium Loss Maps to Chromosome 11q23

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Hereditary Isolated Renal Magnesium Loss Maps to Chromosome 11q23 Iwan C. Meij, Kathrin Saar, Lambert P.W.J. van den Heuvel, Gudrun Nuernberg, Martin Vollmer, Friedhelm Hildebrandt, André Reis, Leo A.H. Monnens, Nine V.A.M. Knoers The American Journal of Human Genetics Volume 64, Issue 1, Pages 180-188 (January 1999) DOI: 10.1086/302199 Copyright © 1999 The American Society of Human Genetics Terms and Conditions

Figure 1 Pedigrees of families A and B, with autosomal dominant isolated renal hypomagnesemia. Blackened symbols denote affected family members. For haplotypes, linked genotypes are depicted as blackened bars; inferred phenotypes are within parentheses, and, if unknown, are denoted by a question mark (?); and critical recombinants (in individuals III.10 and III.12 in family A) are indicated by an upward-facing arrow (↑). The proband in family A could not be haplotyped. In each family, the proband is indicated by an asterisk (*). The American Journal of Human Genetics 1999 64, 180-188DOI: (10.1086/302199) Copyright © 1999 The American Society of Human Genetics Terms and Conditions

Figure 1 Pedigrees of families A and B, with autosomal dominant isolated renal hypomagnesemia. Blackened symbols denote affected family members. For haplotypes, linked genotypes are depicted as blackened bars; inferred phenotypes are within parentheses, and, if unknown, are denoted by a question mark (?); and critical recombinants (in individuals III.10 and III.12 in family A) are indicated by an upward-facing arrow (↑). The proband in family A could not be haplotyped. In each family, the proband is indicated by an asterisk (*). The American Journal of Human Genetics 1999 64, 180-188DOI: (10.1086/302199) Copyright © 1999 The American Society of Human Genetics Terms and Conditions

Figure 2 Left, Ideogram of chromosome 11. a, Closest recombinants (in individuals III.10 and III.12 in family A), limiting the linkage interval to a 5.6-cM region between D11S4142 and D11S4171. Marker D11S924 was not informative for individual III.12. b, Inferred haplotypes of the great-grandfathers (individuals I.1 and I.3 in families A and B, respectively). Recombinations defining the haplotype-shared region were divided arbitrarily between both individuals. Haplotype sharing is shown between D11S4111 and D11S4107. The American Journal of Human Genetics 1999 64, 180-188DOI: (10.1086/302199) Copyright © 1999 The American Society of Human Genetics Terms and Conditions

Figure 3 Four-point analysis (disease locus and three marker loci), calculated by VITESSE (O'Connell and Weeks 1995), for the region from marker D11S927 to marker D11S934. The highest LOD score (8.24) is indicated by a downward-pointing arrowhead (▾). The American Journal of Human Genetics 1999 64, 180-188DOI: (10.1086/302199) Copyright © 1999 The American Society of Human Genetics Terms and Conditions