Acute onset of hematuria and proteinuria associated with multiorgan involvement of the heart, liver, pancreas, kidneys, and skin in a patient with Henoch–Schönlein.

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Acute onset of hematuria and proteinuria associated with multiorgan involvement of the heart, liver, pancreas, kidneys, and skin in a patient with Henoch–Schönlein purpura M. Zaidi, N. Singh, M. Kamran, N. Ansari, S.H. Nasr, A. Acharya Kidney International Volume 73, Issue 4, Pages 503-508 (February 2008) DOI: 10.1038/sj.ki.5002662 Copyright © 2008 International Society of Nephrology Terms and Conditions

Figure 1 CT scan of the abdomen and biopsy of skin and kidney. (a) Computer tomography scan of the abdomen shows significant thickening and edema of jejunum (arrow) (60 × 60 mm (300 × 300 DPI)). (b) The skin biopsy shows leukocytoclastic vasculitis. The dermal small vessels display endothelial cell swelling (arrowhead) and are infiltrated and surrounded by neutrophils, many of which show fragmentation of nuclei (karyorrhexis) (arrows) (hematoxylin–eosin (H&E), original magnification × 600). (c) A glomerulus shows compression of the tuft by a segmental cellular crescent (arrow) admixed with fibrin (arrowhead). The underlying tuft exhibits mild segmental mesangial hypercellularity (H&E, original magnification × 600). (d) On immunofluorescence, there is intense positivity for IgA in a global mesangial distribution (original magnification × 400). Kidney International 2008 73, 503-508DOI: (10.1038/sj.ki.5002662) Copyright © 2008 International Society of Nephrology Terms and Conditions