Ontogeny of platelet function

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Presentation transcript:

Ontogeny of platelet function by Andreas Margraf, Claudia Nussbaum, and Markus Sperandio BloodAdv Volume 3(4):692-703 February 26, 2019 © 2019 by The American Society of Hematology

Andreas Margraf et al. Blood Adv 2019;3:692-703 © 2019 by The American Society of Hematology

Important platelet expression and activation responses in the neonate. Andreas Margraf et al. Blood Adv 2019;3:692-703 © 2019 by The American Society of Hematology

Ontogenetic regulation of platelet function. Ontogenetic regulation of platelet function. Experimental data suggest a balanced environment in which platelet function is tightly regulated to achieve an age-dependent modulation of platelet responses. Andreas Margraf et al. Blood Adv 2019;3:692-703 © 2019 by The American Society of Hematology

Age-mismatch transfusion of platelet concentrates and possible adverse events. Age-mismatch transfusion of platelet concentrates and possible adverse events. Currently, platelet concentrates are collected from adult donors. Adult platelets feature a distinct phenotype that is different from the physiologic properties of neonatal platelets. Possible harmful effects have to be considered and investigated in more detail. TRALI, transfusion-related acute lung injury; ulVWF, unusually large VWF. Andreas Margraf et al. Blood Adv 2019;3:692-703 © 2019 by The American Society of Hematology