Aquaporins in the kidney: Emerging new aspects

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Aquaporins in the kidney: Emerging new aspects Tadashi Yamamoto, Sei Sasaki Kidney International Volume 54, Issue 4, Pages 1041-1051 (October 1998) DOI: 10.1046/j.1523-1755.1998.00123.x Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 1 Phylogenetic analysis of the MIP/AQP proteins. Amino acid sequences are aligned and analyzed by computer using a Cluster V software. The family may be separated into two subfamilies indicated by a dotted line. Kidney International 1998 54, 1041-1051DOI: (10.1046/j.1523-1755.1998.00123.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 2 Schematic diagram of aquaporin distribution in nephron segments. AQP1 is present on both the apical and basolateral membranes of proximal tubular and thin descending limb epithelial cells and also the descending vasa recta endothelium. AQP2 locates predominantly in the subapical cytoplasm and on the apical membrane of collecting duct principal cells. Both AQP3 and AQP4 are primarily present on the basolateral membrane of collecting duct principal cells with different segmental localization; AQP3 is intense in cortical and outer medullary collecting ducts and AQP4 is exclusively found in inner medullary collecting ducts. AQP7 is presumed to be present on apical membrane of proximal straight tubular epithelial cells. AQP6 is not shown as it has not yet been localized. Kidney International 1998 54, 1041-1051DOI: (10.1046/j.1523-1755.1998.00123.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 3 Ribonuclease protection assay for mammalian aquaporins in rat systemic organs. Total RNA (10 μg each) was hybridized with32P-labeled antisense cRNA probe for rat AQP1 (A), AQP2 (B), AQP3 (C), AQP4 (D), AQP5 (E), AQP7 (F) or AQP8 (G) mRNA and probe for glyceraldehyde-3-phosphate dehydrogenase (GAPDH) mRNA simultaneously.32P-labeled cRNA probes protected from riboneclease digestion are detected by autoradiography after gel electrophoresis. Kidney International 1998 54, 1041-1051DOI: (10.1046/j.1523-1755.1998.00123.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Kidney International 1998 54, 1041-1051DOI: (10. 1046/j. 1523-1755 Kidney International 1998 54, 1041-1051DOI: (10.1046/j.1523-1755.1998.00123.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Kidney International 1998 54, 1041-1051DOI: (10. 1046/j. 1523-1755 Kidney International 1998 54, 1041-1051DOI: (10.1046/j.1523-1755.1998.00123.x) Copyright © 1998 International Society of Nephrology Terms and Conditions