JPIAMR – Activity Update Laura Marin JPIAMR Head of Secretariat Swedish Research Council 02 April 2019

AMR is one of the ten threats to global health (WHO, 2019) AMR threatens a return to the pre-antibiotic era Annually in the EU: 33,100 patients die from multidrug resistant bacteria annually (EARS-net) extra health-care costs and productivity losses of at least €1500 million Euro per year AMR projection (2050): 10 million people die each year worldwide (O’Neill report)

Joint Programming Initiative on Antimicrobial Resistance Mission: To join forces across nations by leading the alignment, coordination, and support to Antimicrobial Resistance One Health collaborative research and global policy activities International collaborative platform that: aligns national research funding coordinates AMR research and funding on a global scale supports collaborative action for filling knowledge gaps on AMR with a One Health perspective

Uniting 27 countries to address AMR JPIAMR: A Global Organisation Uniting 27 countries to address AMR The European Commission (DG Research) is a full non voting member JPIAMR member states

JPIAMR Governance Structure NATIONAL EXPERT PANELS & Mirror Groups MANAGEMENT BOARD SCIENTIFIC ADVISORY BOARD STEERING COMMITTEE SECRETARIAT Core Call Steering Group WG1 Evaluation WG2 Governance WG3 Globalisation WG4 Policy Alignment WG5/6 Research Alignment WG7 Industry relations

JPIAMR Steering Committee Carlos Segovia, Spain (Chair) Jan-Ingvar Jönsson, Sweden (Vice-Chair) Antoine Andremont, France Joachim Klein, Germany Jonathan Pearce, UK Richard Gordon, South Africa  

JPIAMR Boards JPIAMR Working Groups Board Chair Secretariat Contact SC Carlos Segovia, Spain Laura M MB SAB Jean-Yves Madec. France Linda Core Call Group Maria Starborg, Sweden Maria JPIAMR Working Groups WG NAME WG Chair WP LEADER Secretariat Contact   WG Governance Rafael, Spain ICIII, Spain Patriq WG Globalisation Akin, Germany DLR, Germany Laura M WG Policy Alignment Karin, Sweden SRC, Sweden Patriq, Laura P WG Research Alignment Linda, NL Zonw, NL Laura P WG VRI Edith, Canada WG RI Margeet, NL Maria S WG Industry Jonathan, UK ANR, France WGs Coordination

JPIAMR CENTRAL SECRETARIAT at the Swedish Research Council (5FT) Head of Secretariat Laura Marin Senior Officers Calls supervision Laura Plant, Patriq Fagerstedt Maria Starborg VRI Coordinator Edith Brochu Analyst Evaluation Analysis Shawon Lahiri Communication Officer Anders Bjers Administration Financial Administration Anna Sundin Mikaela Laine

JPIAMR joint actions: international coordination platform Identifiying reserach priorities and gaps: mappings Strategic Workshops Joint calls for networks Joint calls for research proposals AMR international policy actions JPIAMR-Virtual Research Institute

Discovery of new antibiotics and therapeutic alternatives, and the improvement of current antibiotics and treatment regimens Development and improvement of diagnostics to support the use of antibiotics and alternatives to antibiotics Optimisation of surveillance systems to understand the drivers and burden of AMR in a One Health perspective Understanding and preventing the transmission of AMR The role of the environment in the selection and spread of AMR Investigation and improvement of infection prevention and control measures in One Health settings Identifying the research needs: The JPIAMR Strategic Research and Innovation Agenda Interventions Therapeutics Diagnostics Environment Transmission Surveillance

SRIA roadmaps of action 2019-2023 Experts workshops Steering Committee Consultation SAB consultation MB survey Secretariat preparations Planning of future calls and activities to support the scientific community

JPIAMR mapped national research investment: an overview National funding from 22 countries and the European Commission and the Wellcome Trust 6 JPIAMR priority areas Therapeutics, Diagnostics, Interventions, Transmission, Surveillance and Environment Increase in national investments to AMR research Need more investment with One Health approach 1 939 AMR projects 87% projects in antibiotic resistance 1 794 M€ total investment Check the dashboard for more info www.jpiamr.eu/amr-research-funding-dashboard/ Majority of investment is in Therapeutics Investment in Environment is low

Global AMR research investments and projects Dashboard: Database on AMR research landscape

Distribution of investment at national level per priority area of research in 2014 and 2017 JPIAMR mapping A better overall distribution of investment into the different priority areas categorised under the JPIAMR-SRA was observed in the 2017 JPIAMR mapping. Majority of investment is in therapeutics; but pipeline still empty A large gap for investments in environment at national levels still exists. Need to continue more efforts with One Health approach

JPIAMR workshops 2019 Year Workshops 2019 VRI Network Start-up, February Surveillance Network Start-up, February AMR in Latin America, May AMR in Eastern Europe, June AMR meeting in South Korea, December

Global AMR Research Funder Total of 9 joint transnational research calls Basic, pre-clinical and phase 1 clinical trials To date 49 projects, 30 networks in AMR research have received over 65 M€ from JPIAMR

JPIAMR funded 20 projects in Therapeutics research 100 partners in 17 countries 25M Euros invested JPIAMR supported research projects addressing pathogens categorised under WHO Priority Pathogens List Distribution of JPIAMR funded projects on the basis of pathogens studied WHO priority pathogens Medium (Priority 3) Critical (Priority 1) High (Priority 2) TB Others

JPIAMR funded 19 projects in Transmission research 118 partners in 17 countries 30M Euros invested Human (Health care facilities) Environment (Wastewater Treatment Plants) Animal (Livestock, pets)

JPIAMR Calls 2019-2023 Year Funding scheme Call Name Priority topics Investment (M €) 2019 Projects Development of diagnostic and surveillance tools, technologies and methods to detect antimicrobial resistance (AMR) Diagnostics Surveillance >20M 2020 Networks Network + ERAnet Emerging Pollutants and Pathogens 2019 1st calls (jointly call with JPIWATER and JPIOCEANS) Environment Transmission   2021 JPIAMR ACTION: AntimiCrobial Transmission InterventiONs Intervention

JPIAMR-Virtual Research Institute Connecting Bridging Partnerships, Collaborations, Forums, Workshops, Webinars Knowledge Access Enabling Global Access, Mappings, Frameworks, Blueprints, Expertise, Knowledge Transfers Data Sharing Online Sharing Platforms, Libraries, Catalogues JPIAMR-VRI Scientific Innovation Building Evidence in all One Health domains of AMR Capacity Building Training, Virtual Education, Train the Trainers, Exchange Programs Awareness Developing and Sharing research results, Promoting AMR in the Global Agenda

JPIAMR-Virtual Research Institute Research Areas A B C D E F 1 Connecting 2 Access 3 Data Sharing Modules Scientific Innovation 4 Capacity Building 5 6 Awareness   Therapeutics Diagnostics Surveillance Transmission Environment Interventions VRI programmes

JPIAMR Communications Implementation GDPR rules; databases management New service for Newsletters. Video: Interviews – workshops Implementation of the new designs of logo, brand colours, templates, etc. Development communication materials Developed communications of the JPIAMR-VRI Continued communication of the JPIAMR Research Funding Dashboard. Preparing launch of the SRIA. Traffic and engagement in digital channels is increasing. More requests from media. Guidelines for media relations have been developed. Planning update website

Communications www.jpiamr.eu 8 867 Unique pageviews: The 9th Call on AMR Diagnostics and Surveillance. (ATH) 2 160 New users from USA. Now the top location. India is No. 2 with 1 341. 15 049 New users in Q1 2019. Up from 8 146 in Q1, 2019. 910 Unique pageviews: AMR Research Funding Dashboard in Q1, 2019.

@jpiamr Communications Twitter audience growth:Q1 2019

@jpiamr Communications Twitter Engagement: Q1 2019

International representation Communications International representation European Antibiotic Awareness Day (EAAD), Brussels, 16 November 2018 AMR call for Action (UN event), Accra (Ghana), 19 November 2018 EU Parliament, Brussels, 29 January 2019 ICARS meeting, Washington DC, February 2019 EU AMR One Health Network meeting 12th Berlin Conference on Life Sciences UN Water Conference Global Hub workshop FEMS

Many more activities running... And more to come in 2019!!! Membership management Expansion of the membership Governance reinforcement – self-evaluation Sustainability International coordination Peer review guidelines and new funding instruments National Alignment, Policy Alignment Industry relations Research Infrastructures Förtydliga orden som är i pelarna. Hur förtydligar vi dem rent illustrativt? Först pelarna, sedan agendan.

JPIAMR strategy NEXT: JPIAMR Roadmaps of Actions 2019-2023 The Strategic Research Agenda (2014) JPIAMR Implementation Plan 2015-2018 JPIAMR Short Term Strategy 2018-2020 JPIAMR Long Term Strategy 2020-2025 NEXT: JPIAMR Roadmaps of Actions 2019-2023 Update Strategy New Implementation Plan 2021-2023

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