Transgene expression of Nlrp1b sensitizes BMDMs to cell death upon DPP8/DPP9 inhibition. Transgene expression of Nlrp1b sensitizes BMDMs to cell death.

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Transgene expression of Nlrp1b sensitizes BMDMs to cell death upon DPP8/DPP9 inhibition. Transgene expression of Nlrp1b sensitizes BMDMs to cell death upon DPP8/DPP9 inhibition. (A–H) B6 or B6Nlrp1b+ BMDMs were left untreated or treated with 10, 25, or 40 μM of VBP (A), acetyl-VBP (B), cyclic-VBP (C), sitagliptin (D), UAMC39 (E), UAMC1110 (F), KYP-2047/UAMC714 (G), or 1G244 (H) in media containing SG and imaged on an Incucyte platform. In all graphs, the number of positive cells was quantified relative to a Triton X100–treated well considered 100%. Values represent mean ± SD of technical duplicates of a representative experiment from three biological repeats. Nathalia M de Vasconcelos et al. LSA 2019;2:e201900313 © 2019 de Vasconcelos et al.