Incomplete biochemical adaptation of vein grafts to the arterial environment in terms of prostacyclin production Peter D. Cahill, M.D. *, Bruce A. Brown,

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Presentation transcript:

Incomplete biochemical adaptation of vein grafts to the arterial environment in terms of prostacyclin production Peter D. Cahill, M.D. *, Bruce A. Brown, B.A., Cynthia E. Handen, B..A., Jon C. Kosek, M.D., D.Craig Miller, M.D., Gaye-Marie Bulotti, Scott Angell, George E. Sarris, M.D. Journal of Vascular Surgery Volume 6, Issue 5, Pages 496-503 (November 1987) DOI: 10.1016/0741-5214(87)90309-0 Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 1 Standard canine surgical preparations for implantation of four reversed, ischemic femoral vein grafts into bilateral carotid and femoral arteries. Journal of Vascular Surgery 1987 6, 496-503DOI: (10.1016/0741-5214(87)90309-0) Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 2 Template incubation chamber designed originally by Eldor et al.16 and used in these experiments for vessel radioimmunoassay preparation. Vessel (vein, artery, or graft) is placed between Lucite plates, providing exposure of incubation fluid to a known and uniform endothelial surface area for each vessel. Three vessels may be assayed simultaneously. (From Henderson et al. Biochemical (functional) adaptation of “arterialized” vein grafts. Ann Surg 1986;203:340.) Journal of Vascular Surgery 1987 6, 496-503DOI: (10.1016/0741-5214(87)90309-0) Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 3 Depiction of basal PGF1α production by vein, artery, and graft. Note that graft and arterial PGI2 productions exceed venous levels and are nearly equivalent. Values indicate group means (±SEM). Values for p derived from Student's t tests for unpaired data. Journal of Vascular Surgery 1987 6, 496-503DOI: (10.1016/0741-5214(87)90309-0) Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 4 Depiction of arachidonic acid—stimulated production of PGF1α by vein, artery, and vein grafts implanted for 12 weeks. Note that venous and arterial production exceeds basal levels (see Fig. 3), whereas stimulated graft production is nearly equal to basal graft and to stimulated vein. Values indicate group means (±SEM), and p values are from Student's t tests for unpaired data. Journal of Vascular Surgery 1987 6, 496-503DOI: (10.1016/0741-5214(87)90309-0) Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions