Tuning to visual stimuli in wild-type, APOEnull, APP/PSEN1, and APP/PSEN1/APOEnull mice. Tuning to visual stimuli in wild-type, APOEnull, APP/PSEN1, and.

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Tuning to visual stimuli in wild-type, APOEnull, APP/PSEN1, and APP/PSEN1/APOEnull mice. Tuning to visual stimuli in wild-type, APOEnull, APP/PSEN1, and APP/PSEN1/APOEnull mice. (A) Scatter dot plots representing the DSI (left panel) and OSI (right panel) calculated after recording visually evoked response in wild-type, APOEnull, APP/PSEN1, and APP/PSEN1/APOEnull mice. (B) Cumulative distributions of DSI and OSI calculated for all responding neurons showing a shift towards an increased proportion of poorly tuned neurons in APP/PSEN1 as compared with the other genotypes, with the exception of the OSI distribution in APOEnull mice. n = 18 wild-type, n = 13 APOEnull, n = 18 APP/PSEN1, and n = 16 APP/APOEnull mice (adult and old cohorts); linear mixed model after log-transformation of the data; *P < 0.05. Eloise Hudry et al. LSA 2019;2:e201900325 © 2019 Hudry et al.