Fertility and Sterility

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Presentation transcript:

Fertility and Sterility Influence of thyroid hormone on mouse preantral follicle development in vitro Sandra Cecconi, Sc.D., Gianna Rossi, B.Sc., Giovanni Coticchio, Ph.D., Guido Macchiarelli, M.D., Andrea Borini, M.D., Rita Canipari, Sc.D. Fertility and Sterility Volume 81, Pages 919-924 (March 2004) DOI: 10.1016/j.fertnstert.2003.11.014

FIGURE 1 Growth rate of follicles cultured for 6 days with serum (♦), T3 (◊), FSH (■) and FSH+T3 (□). Groups with different letters differ in a statistically significant fashion. Cecconi. T3 and follicle development.Fertil Steril 2004. Fertility and Sterility 2004 81, 919-924DOI: (10.1016/j.fertnstert.2003.11.014)

FIGURE 2 Dose-dependent effect of T3 on the proportion of FSH-stimulated follicles developing the AC after 6 days of culture. Groups with different letters differ in a statistically significant fashion. Cecconi. T3 and follicle development.Fertil Steril 2004. Fertility and Sterility 2004 81, 919-924DOI: (10.1016/j.fertnstert.2003.11.014)

FIGURE 3 Proportions of follicles developing the AC after 6 days of culture in the presence of FSH, alone or in combination with T3. In some experiments, T3 was removed from the culture medium after 1 to 5 days and follicles were further cultured up to a total of 6 days. Groups with different letters differ in a statistically significant fashion. Cecconi. T3 and follicle development.Fertil Steril 2004. Fertility and Sterility 2004 81, 919-924DOI: (10.1016/j.fertnstert.2003.11.014)

FIGURE 4 Rates of (A) GVBD and (B) PB1 extrusion in in vitro matured oocytes released from IVG follicles with (■) or without (□) the AC. About 80 to 100 oocytes were analyzed for each experimental condition. Groups with different letters differ in a statistically significant fashion. Cecconi. T3 and follicle development.Fertil Steril 2004. Fertility and Sterility 2004 81, 919-924DOI: (10.1016/j.fertnstert.2003.11.014)