Volume 69, Issue 11, Pages (June 2006)

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Presentation transcript:

Volume 69, Issue 11, Pages 1925-1927 (June 2006) Rapamycin and chronic kidney disease: beyond the inhibition of inflammation Y. Liu Kidney International Volume 69, Issue 11, Pages 1925-1927 (June 2006) DOI: 10.1038/sj.ki.5001543 Copyright © 2006 International Society of Nephrology Terms and Conditions

Figure 1 Potential actions of rapamycin in chronic renal fibrosis. Mammalian target of rapamycin (mTOR), through its downstream effectors, plays a critical role in regulating a variety of cellular processes, such as cell proliferation and hypertrophy, T-cell infiltration and clonal expansion, and tubular epithelial-to-mesenchymal transition (EMT). Arrows represent activation, and bars represent inhibition. p70S6K, p70 ribosomal S6 kinase; 4E-BP1, eukaryotic initiation factor-4E-binding protein-1; eIF-4E, eukaryotic initiation factor-4E; cdk, cyclin-dependent kinase. Kidney International 2006 69, 1925-1927DOI: (10.1038/sj.ki.5001543) Copyright © 2006 International Society of Nephrology Terms and Conditions