Effects of moderate versus deep hypothermic circulatory arrest and selective cerebral perfusion on cerebrospinal fluid proteomic profiles in a piglet.

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Presentation transcript:

Effects of moderate versus deep hypothermic circulatory arrest and selective cerebral perfusion on cerebrospinal fluid proteomic profiles in a piglet model of cardiopulmonary bypass Taslim Allibhai, MD, Robert DiGeronimo, MD, John Whitin, PhD, Jorge Salazar, MD, Tom To-Sang Yu, Xuefeng Bruce Ling, PhD, Harvey Cohen, MD, PhD, Patricia Dixon, Ashima Madan, MD The Journal of Thoracic and Cardiovascular Surgery Volume 138, Issue 6, Pages 1290-1296 (December 2009) DOI: 10.1016/j.jtcvs.2009.06.001 Copyright © 2009 Terms and Conditions

Figure 1 CSF/serum protein ratio (n = 5/group). Data are presented as a box plot showing median line and 25th and 75th percentiles, respectively. Group 1 = 18°C HCA without SCP; group 2 = 18°C HCA with SCP; and group 3 = 25°C HCA with SCP. A, P < .01 versus control; b, P < .05 versus 18°C SCP. CSF, Cerebrospinal fluid; HCA, hypothermic circulatory arrest; SCP, selective cerebral perfusion. The Journal of Thoracic and Cardiovascular Surgery 2009 138, 1290-1296DOI: (10.1016/j.jtcvs.2009.06.001) Copyright © 2009 Terms and Conditions

Figure 2 Averaged spectra for the control group obtained using the three acquisition modes of the mass spectrometer, optimized for small, medium, and large proteins The Journal of Thoracic and Cardiovascular Surgery 2009 138, 1290-1296DOI: (10.1016/j.jtcvs.2009.06.001) Copyright © 2009 Terms and Conditions

Figure 3 Venn diagram representing the relationship between the significantly different peaks from each of the three surgical groups compared with controls. Group 1 = 18°C HCA (hypothermic circulatory arrest) without SCP (selective cerebral perfusion); group 2 = 18°C HCA with SCP; and group 3 = 25°C HCA with SCP. The Journal of Thoracic and Cardiovascular Surgery 2009 138, 1290-1296DOI: (10.1016/j.jtcvs.2009.06.001) Copyright © 2009 Terms and Conditions