University of sulaimani Tablet dosage form Aram I. Ibrahim University of sulaimani College of pharmacy Dep.of pharmaceutics
Introduction tablets are solid dosage form each containing a single dose of one or more active substances. Tablets are intended for oral administration. Tablets can be: Swallowed whole Chewed Dissolved or dispersed in water Retained in the mouth
Advantages Ease of administration Stable Accurate dose Easy to handle and transfer Cheap
Disadvantages Tablets are not suitable dosage form for drugs that are: Resist compression Poor wetting and slow dissolution properties Bitter-tasting drugs, drugs with an unpleasant odor.
Tablet formation Tablets are normally formed by powder compression. The compression takes place in a die by the action of two punches
Tablet processing steps
Tablet press types Single-punch press Rotary press
Tablet excipients Filler e.g., lactose, sucrose, mannitol, and calcium phosphate • Disintegrants e.g., starch and cellulose • Glidant e.g., Talc, silica • Lubricant e.g., magnesium stearate and sodium lauryl sulphate • Antiadherent talc and starch
Types of lubricants
Types of lubricants cont.
Types of antiadherents
Procedure Mix all the required powders in a bottle and shake it for 3 minutes. Put the powder blend in to the hopper of the tablet press machine. Start to press the powder and collect the tablers. Store your tablets in a tight closed container for further investigation in the next lab.
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