Role of increased oxygen free radical activity in the pathogenesis of uremic hypertension  Nosratola D. Vaziri, Fariba Oveisi, Yaoxian Ding  Kidney International  Volume 53, Issue 6, Pages 1748-1754 (June 1998) DOI: 10.1046/j.1523-1755.1998.00947.x Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 1 Hematocrit, body weight, plasma creatinine concentration and creatinine clearance obtained at the end of the study period in the normal control group (□), placebo-treated CRF group (), and lazaroid-treated CRF animals (). N = 6 animals in each group. *P < 0.05 versus control (Duncan’s multiple range test). #P < 0.05 versus CRF group (Duncan’s multiple range test). Kidney International 1998 53, 1748-1754DOI: (10.1046/j.1523-1755.1998.00947.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 1 Hematocrit, body weight, plasma creatinine concentration and creatinine clearance obtained at the end of the study period in the normal control group (□), placebo-treated CRF group (), and lazaroid-treated CRF animals (). N = 6 animals in each group. *P < 0.05 versus control (Duncan’s multiple range test). #P < 0.05 versus CRF group (Duncan’s multiple range test). Kidney International 1998 53, 1748-1754DOI: (10.1046/j.1523-1755.1998.00947.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 1 Hematocrit, body weight, plasma creatinine concentration and creatinine clearance obtained at the end of the study period in the normal control group (□), placebo-treated CRF group (), and lazaroid-treated CRF animals (). N = 6 animals in each group. *P < 0.05 versus control (Duncan’s multiple range test). #P < 0.05 versus CRF group (Duncan’s multiple range test). Kidney International 1998 53, 1748-1754DOI: (10.1046/j.1523-1755.1998.00947.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 2 Tail systolic arterial blood pressure and plasma concentrations of lipid peroxidation product, malondialdehyde (MDA) before, during and after placebo or lazaroid therapies in the placebo-treated CRF group and lazaroid-treated CRF animals, respectively. Also included are data obtained in the normal control group. N = 6 animals in each group. Symbols are: (□) CRF-placebo; (○) CRF-lazaroid; (⋄) normal.*P < 0.05 versus control group (ANOVA and Duncan’s multiple range test); #P < 0.05 versus CRF group (ANOVA and Duncan’s multiple range test). Kidney International 1998 53, 1748-1754DOI: (10.1046/j.1523-1755.1998.00947.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 3 Correlation between arterial blood pressure in the entire study groups (A) and the lazaroid-treated group before, during and two weeks after completion of lazaroid therapy (B). Symbols are: (□) CRF-placebo; (○) CRF-lazaroid; (⋄) normal; (•) lazaroid. In A, r = 0.677, P < 0.005; in B, r = 0.573; P < 0.05. Kidney International 1998 53, 1748-1754DOI: (10.1046/j.1523-1755.1998.00947.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 4 Plasma concentration and urinary excretion of total nitrate/nitrite (NOx) in the normal control group, placebo-treated CRF (CRF-PL) group and lazaroid-treated CRF (CRF-LZ) group. N = 6 animals in each group. *P < 0.001 versus control group (ANOVA and Duncan’s multiple range test). Kidney International 1998 53, 1748-1754DOI: (10.1046/j.1523-1755.1998.00947.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 5 Change in intra-arterial blood pressure from baseline and urinary excretion of total nitrates/nitrites (NOx) in response to intravenous infusions of superoxide dismutase (SOD), a superoxide quencher, catalase (CAT), a H2O2quencher, and the hydroxyl radical scavenger, dimethylthiourea (DMTU), in normal control (□) and CRF () groups. N = 6 animals in each group. *P < 0.05 (Student’s t-test CRF vs. control). Kidney International 1998 53, 1748-1754DOI: (10.1046/j.1523-1755.1998.00947.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 5 Change in intra-arterial blood pressure from baseline and urinary excretion of total nitrates/nitrites (NOx) in response to intravenous infusions of superoxide dismutase (SOD), a superoxide quencher, catalase (CAT), a H2O2quencher, and the hydroxyl radical scavenger, dimethylthiourea (DMTU), in normal control (□) and CRF () groups. N = 6 animals in each group. *P < 0.05 (Student’s t-test CRF vs. control). Kidney International 1998 53, 1748-1754DOI: (10.1046/j.1523-1755.1998.00947.x) Copyright © 1998 International Society of Nephrology Terms and Conditions