Structural relatedness of plant food allergens with specific reference to cross-reactive allergens: An in silico analysis John A. Jenkins, PhD, Sam Griffiths-Jones,

Slides:

Advertisements

Similar presentations

Joint modeling of parentally reported and physician-confirmed wheeze identifies children with persistent troublesome wheezing Danielle C.M. Belgrave, MSc,

Advertisements

Control of immunopathology during chikungunya virus infection Caroline Petitdemange, PhD, Nadia Wauquier, PhD, Vincent Vieillard, PhD Journal of Allergy.

Characteristics of childhood peanut allergy in the Australian Capital Territory, 1995 to 2007 Raymond James Mullins, MBBS, PhD, FRACP, FRCPA, Keith B.G.

Peter Vadas, MD, PhD, Boris Perelman, PhD, Gary Liss, MD, MS

Advances in Diagnosing Peanut Allergy

Allergen immunotherapy: A practice parameter third update

Kyoung-Bok Min, MD, PhD, Jin-Young Min, PhD

Fatty acids, inflammation, and asthma

Eosinophilic gastrointestinal disease suggestive of pathogenesis-related class 10 (PR- 10) protein allergy resolved after immunotherapy Liliane De Swert,

Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD

Ann-Marie M. Schoos, MD, PhD, Jacob D

Major rabbit allergen Ory c 3: What could be its possible role as a sensitizing agent in real life? Gennaro Liccardi, MD, Antonello Salzillo, MD, Maria.

Delineating the specificity of an IgE-encoding transcriptome

Is 9 more than 2 also in allergic airway inflammation?

Desensitization to Chemotherapeutic Agents

Fatty acids, inflammation, and asthma

An Infant with Atopic Dermatitis and Itching After Ingestion of Milk

Robert G. Hamilton, PhD, John Oppenheimer, MD

Analysis of glutathione S-transferase allergen cross-reactivity in a North American population: Relevance for molecular diagnosis Geoffrey A. Mueller,

Rising prevalence of asthma is sex-specific in a US farming population

Loss of allergenic proteins during boiling explains tolerance to boiled peanut in peanut allergy Paul J. Turner, FRACP, PhD, Sam Mehr, FRACP, Rebekah.

Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J

Allergy testing in predicting outcome of open food challenge to peanut

A classification of plant food allergens

Advances in Diagnosing Peanut Allergy

Nonadherence to Asthma Treatment: Getting Unstuck

Peter M. Wolfgram, MD, David B. Allen, MD

Etiology of asthma exacerbations

Jewlya Lynn, PhD, Sophie Oppenheimer, MS, MPH, Lorena Zimmer, MA

Molecular properties of food allergens

Jon Genuneit, MD, MSc Journal of Allergy and Clinical Immunology

The Editors' Choice Journal of Allergy and Clinical Immunology

Phillip Lieberman, MD, Michael Tankersley, MD

Time for a paradigm shift in asthma treatment: From relieving bronchospasm to controlling systemic inflammation Leif Bjermer, MD Journal of Allergy.

News & Notes Journal of Allergy and Clinical Immunology

Atopic dermatitis: A practice parameter update 2012

Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management Scott H. Sicherer, MD, Hugh A. Sampson, MD Journal.

Biosimilars and drug development in allergic and immunologic diseases

News Beyond Our Pages Journal of Allergy and Clinical Immunology

Peter Vadas, MD, PhD, Boris Perelman, PhD, Gary Liss, MD, MS

John A. Jenkins, PhD, Heimo Breiteneder, PhD, E. N. Clare Mills, PhD

What is an “eosinophilic phenotype” of asthma?

Cephalosporin Side Chain Cross-reactivity

Allergenic significance of cephalosporin side chains

H. William Kelly, PharmD Journal of Allergy and Clinical Immunology

Cockroach allergens: Coping with challenging complexity

Autophagy: Nobel Prize 2016 and allergy and asthma research

News & Notes Journal of Allergy and Clinical Immunology

Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment

Allergens are distributed into few protein families and possess a restricted number of biochemical functions Christian Radauer, PhD, Merima Bublin, PhD,

Advances in the approach to the patient with food allergy

Geographic variability in childhood asthma prevalence in Chicago

A single intervention for cockroach control reduces cockroach exposure and asthma morbidity in children Felicia A. Rabito, PhD, MPH, John C. Carlson,

Prevention of food allergy: Beyond peanut

News Beyond Our Pages Journal of Allergy and Clinical Immunology

What can urban/rural differences in food allergy prevalence tell us about the drivers of food allergy? Katrina J. Allen, MBBS, BMedSc, FRACP, FAAAI,

Reply Journal of Allergy and Clinical Immunology

The role of indoor allergens in chronic allergic disease

Thunderstorm-related asthma attacks

Peanut oral immunotherapy decreases IgE to Ara h 2 and Ara h 6 but does not enhance sensitization to cross-reactive allergens Riikka Uotila, MD, Anna.

Measles and immunomodulation

Macrolide antibiotics and asthma treatment

Asthma: The past, future, environment, and costs

Hymenoptera venom protease allergens

Pru p 3 as a marker for symptom severity for patients with peach allergy in a birch pollen environment Sonja Gaier, MSc, Christina Oberhuber, PhD, Wolfgang.

Environmental factors and eosinophilic esophagitis

News & Notes Journal of Allergy and Clinical Immunology

The GILL study: Glycerin-induced local reactions in immunotherapy

Natural history of cow’s milk allergy

Primary prevention of asthma and allergy

Presentation transcript:

Structural relatedness of plant food allergens with specific reference to cross-reactive allergens: An in silico analysis John A. Jenkins, PhD, Sam Griffiths-Jones, PhD, Peter R. Shewry, PhD, Heimo Breiteneder, PhD, E.N. Clare Mills, PhD Journal of Allergy and Clinical Immunology Volume 115, Issue 1, Pages 163-170 (January 2005) DOI: 10.1016/j.jaci.2004.10.026 Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 1 Distribution within protein families, as classified by Pfam using allergen sequences from the PROTALL and FARRP databases. A, PROTALL-FARRP (black); PROTALL food allergen (gray); PROTALL-FARRP (single sequence per allergen; white); B, FARRP respiratory allergen set. Journal of Allergy and Clinical Immunology 2005 115, 163-170DOI: (10.1016/j.jaci.2004.10.026) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 2 Conserved surface residues in the Bet v 1 family. A, Ribbon diagram of Bet v 1a. B, Conserved residues between Bet v 1a and Mal d 1 showing side chains (red), main chains (pink), and nonconserved side chains/main chains (cyan). C, Conserved residues, as in B, for Bet v 1a–Gly m 4 conservation, with P-loop marked. D, Conserved residues, as in B, for Bet v 1a–Api g 1.0101 conservation, with most similar surface region marked. An animated (video) version of this figure is available in the Journal's Online Repository at www.mosby.com/jaci. Journal of Allergy and Clinical Immunology 2005 115, 163-170DOI: (10.1016/j.jaci.2004.10.026) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 3 Conserved surface residues in the nsLTP family. A, Ribbon diagram of corn nsLTP, Zea m 14. B, Surface of Zea m 14, colored to show Pru p 3–Zea m 14 conservation, as in Fig 2. C, Ribbon diagram of wheat nsLTP1. D, Surface of wheat nsLTP, colored to show Pru p 3–wheat conservation, as in Fig 2. An animated (video) version of this figure is available in the Journal's Online Repository at www.mosby.com/jaci. Journal of Allergy and Clinical Immunology 2005 115, 163-170DOI: (10.1016/j.jaci.2004.10.026) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions