F. Henry Ellis, MD, PhD, Xiangjun Xu, MD, PhD, Matthew H

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Presentation transcript:

Malignant transformation of the esophageal mucosa is enhanced in p27 knockout mice F.Henry Ellis, MD, PhD, Xiangjun Xu, MD, PhD, Matthew H. Kulke, MD, Joseph LoCicero, MD, Massimo Loda, MD The Journal of Thoracic and Cardiovascular Surgery Volume 122, Issue 4, Pages 809-814 (October 2001) DOI: 10.1067/mtc.2001.116471 Copyright © 2001 American Association for Thoracic Surgery Terms and Conditions

Fig. 1 Postmortem specimen from a p27 KO mouse after esophagojejunostomy and administration of a carcinogen. Note dilated esophagus proximal to esophagojejunostomy where a tumor (arrow) is clearly visible. The Journal of Thoracic and Cardiovascular Surgery 2001 122, 809-814DOI: (10.1067/mtc.2001.116471) Copyright © 2001 American Association for Thoracic Surgery Terms and Conditions

Fig. 2 Postmortem specimen from a p27 KO mouse showing transition (arrow) from pale squamous epithelium to pink epithelium of Barrett esophagus. While not visible in the gross specimen, islands of squamous mucosa were present at the anastomotic site. The Journal of Thoracic and Cardiovascular Surgery 2001 122, 809-814DOI: (10.1067/mtc.2001.116471) Copyright © 2001 American Association for Thoracic Surgery Terms and Conditions

Fig. 3 Postmortem specimen of a p27 KO mouse after esophagojejunostomy and administration of a carcinogen. Two tumors are visible (arrows). The distal tumor was an adenocarcinoma, and the more proximal tumor was a squamous cell cancer. The Journal of Thoracic and Cardiovascular Surgery 2001 122, 809-814DOI: (10.1067/mtc.2001.116471) Copyright © 2001 American Association for Thoracic Surgery Terms and Conditions

Fig. 4 Hematoxylin and eosin stains of representative pathologic entities in p27 knockout mice. A, Metaplastic Barrett epithelium present within esophageal squamous mucosa. B, Invasive squamous cell carcinoma. C, Invasive adenocarcinoma. D, Invasive adenosquamous carcinoma. (Original magnification ×400.) The Journal of Thoracic and Cardiovascular Surgery 2001 122, 809-814DOI: (10.1067/mtc.2001.116471) Copyright © 2001 American Association for Thoracic Surgery Terms and Conditions