Structure of STAT6CF and N4 site DNA complex.

Slides:

Advertisements

Similar presentations

The first step in sugar transport: crystal structure of the amino terminal domain of enzyme I of the E. coli PEP: sugar phosphotransferase system and.

Advertisements

Structure of a Ternary Transcription Activation Complex

Comparison of Cg-OxyR active-site pocket with previously published structures. Comparison of Cg-OxyR active-site pocket with previously published structures.

Two functional states of human CFTR

Ross Alexander Robinson, Xin Lu, Edith Yvonne Jones, Christian Siebold

Recognition of double‐stranded telomeric DNA

Structures of natural cytotoxicity receptors.

Tsan Xiao, Par Towb, Steven A. Wasserman, Stephen R. Sprang Cell

Structure of an LDLR-RAP Complex Reveals a General Mode for Ligand Recognition by Lipoprotein Receptors Carl Fisher, Natalia Beglova, Stephen C. Blacklow

Structural Basis of Caspase Inhibition by XIAP

Volume 24, Issue 5, Pages (December 2006)

Pentamer–8I21 Fab and Pentamer–9I6 Fab interactions and structural superpositions. Pentamer–8I21 Fab and Pentamer–9I6 Fab interactions and structural superpositions.

Molecular Model of the Human 26S Proteasome

by Alexey Dementiev, Abel Silva, Calvin Yee, Zhe Li, Michael T

Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus

Volume 18, Issue 11, Pages (November 2010)

Structure of RGS4 Bound to AlF4−-Activated Giα1: Stabilization of the Transition State for GTP Hydrolysis John J.G. Tesmer, David M. Berman, Alfred G.

Yvonne Groemping, Karine Lapouge, Stephen J. Smerdon, Katrin Rittinger

Smads “Freeze” When They Ski

Volume 10, Issue 12, Pages (December 2002)

Volume 17, Issue 6, Pages (March 2005)

Hubert Kettenberger, Karim-Jean Armache, Patrick Cramer Cell

The Mechanism of E. coli RNA Polymerase Regulation by ppGpp Is Suggested by the Structure of their Complex Yuhong Zuo, Yeming Wang, Thomas A. Steitz

Volume 15, Issue 1, Pages (January 2007)

Pan2 exploits the asymmetry and forms an extensive interface with the Pan3 dimerStructural details of the complex of ctPan3 PKC bound to the Pan3 interacting.

Volume 20, Issue 6, Pages (December 2005)

Ross Alexander Robinson, Xin Lu, Edith Yvonne Jones, Christian Siebold

Volume 21, Issue 10, Pages (October 2013)

Volume 4, Issue 5, Pages (November 1999)

Volume 17, Issue 3, Pages (March 2009)

Structure of the Yeast Hst2 Protein Deacetylase in Ternary Complex with 2′-O-Acetyl ADP Ribose and Histone Peptide Kehao Zhao, Xiaomei Chai, Ronen Marmorstein

Volume 20, Issue 2, Pages (February 2012)

Volume 90, Issue 1, Pages (July 1997)

Structural Basis for Protein Recognition by B30.2/SPRY Domains

Daniel Peisach, Patricia Gee, Claudia Kent, Zhaohui Xu Structure

Structure of the Catalytic Domain of Human DOT1L, a Non-SET Domain Nucleosomal Histone Methyltransferase Jinrong Min, Qin Feng, Zhizhong Li, Yi Zhang,

Volume 25, Issue 11, Pages e4 (November 2017)

Analysis of Pentamer interfaces.

Volume 3, Issue 5, Pages (May 1999)

Antonina Roll-Mecak, Chune Cao, Thomas E. Dever, Stephen K. Burley

Volume 101, Issue 4, Pages (May 2000)

David Jeruzalmi, Mike O'Donnell, John Kuriyan Cell

Volume 22, Issue 2, Pages (February 2014)

Structural Insights into the pH-Dependent Conformational Change and Collagen Recognition of the Human Mannose Receptor Zhenzheng Hu, Xiangyi Shi, Bowen.

Meigang Gu, Kanagalaghatta R. Rajashankar, Christopher D. Lima

Mechanisms Contributing to T Cell Receptor Signaling and Assembly Revealed by the Solution Structure of an Ectodomain Fragment of the CD3ϵγ Heterodimer

The Structure of the β-Catenin/E-Cadherin Complex and the Molecular Basis of Diverse Ligand Recognition by β-Catenin Andrew H. Huber, William I. Weis

The first step in sugar transport: crystal structure of the amino terminal domain of enzyme I of the E. coli PEP: sugar phosphotransferase system and.

David Jeruzalmi, Mike O'Donnell, John Kuriyan Cell

DNA Synthesis across an Abasic Lesion by Human DNA Polymerase ι

Structure of the Staphylococcus aureus AgrA LytTR Domain Bound to DNA Reveals a Beta Fold with an Unusual Mode of Binding David J. Sidote, Christopher.

Volume 93, Issue 5, Pages (May 1998)

Robert S. Magin, Glen P. Liszczak, Ronen Marmorstein Structure

Volume 23, Issue 12, Pages (December 2015)

Crystal Structure of the Carboxyltransferase Domain of Acetyl-Coenzyme A Carboxylase in Complex with CP Hailong Zhang, Benjamin Tweel, Jiang Li,

Sequence conservation across the Ub-binding sites of human USPs

Crystal structure of STAT6CF-N3 complex and its comparison with STAT6CF-N4 complex structure. Crystal structure of STAT6CF-N3 complex and its comparison.

The positive (blue) and negative (red) electrostatic potential isosurfaces [obtained using APBS (61) and traced in PyMol (62) at 0.7 kT/e] of cytP450cam.

Multiple sequence alignment of STAT6 and other STAT proteins produced by ClusterW and ESpript (espript.ibcp.fr/ESPript/ESPript/). Multiple sequence alignment.

The Crystal Structure of an Unusual Processivity Factor, Herpes Simplex Virus UL42, Bound to the C Terminus of Its Cognate Polymerase Harmon J Zuccola,

The 2.0 å structure of a cross-linked complex between snowdrop lectin and a branched mannopentaose: evidence for two unique binding modes Christine Schubert.

LC8 is structurally variable but conserved in sequence.

Structure of an IκBα/NF-κB Complex

Structural Basis for Kinase-Mediated Macrolide Antibiotic Resistance

(a) Pattern of UWHBs, represented as green segments joining paired α-carbons, for human Hb β-subunit. (a) Pattern of UWHBs, represented as green segments.

Structure of the Histone Acetyltransferase Hat1

The Crystal Structure of an Unusual Processivity Factor, Herpes Simplex Virus UL42, Bound to the C Terminus of Its Cognate Polymerase Harmon J Zuccola,

by Olga Rechkoblit, Yogesh K. Gupta, Radhika Malik, Kanagalaghatta R

Robert S. Magin, Glen P. Liszczak, Ronen Marmorstein Structure

Volume 95, Issue 2, Pages (October 1998)

Presentation transcript:

Structure of STAT6CF and N4 site DNA complex. Structure of STAT6CF and N4 site DNA complex. (A) Schematic diagram showing the domain organization of human STAT6, including N-terminal domain (gray), coiled coil domain (yellow), DNA-binding domain (red), linker domain (orange), SH2 domain (cyan), and TAD domain (gray). The core fragment and phosphorylation site Y641 are indicated. (B) Cartoon diagram of the STAT6CF-N4 complex (in front view). Colors of each domain are the same as in A. (C) Drawing depicting details of the STAT6CF–DNA interface. The side chains of residues (A chain) donating hydrogen bonds are shown as magenta colored sticks, and the hydrogen bonds are shown as yellow dashed lines. The conserved palindromic bases (TTC/GAA) in both sides of the DNA molecule are shown in orange. (D) A schematic drawing highlighting STAT6CF–DNA interactions. Residues forming hydrogen bonds are colored in magenta (D chain) and black (B chain). Jing Li et al. PNAS 2016;113:46:13015-13020 ©2016 by National Academy of Sciences