RNA-Seq analysis of CYR1 cells in the adaptation to acid pH. RNA-Seq analysis of CYR1 cells in the adaptation to acid pH. (A) Black shows the sum of transcripts that were >2-fold different and had an FDR of <0.05; blue shows transcripts that were upregulated at pH 7 and complemented; red shows transcripts that were downregulated at pH 7 and complemented. (B) Overlap of genes differentially regulated by pH in the presence and absence of strain CYR1. (C) Principal component analysis of the cyr1Δ/Δ mutant and CYR1 strain samples at pH 4 and pH 7. Jeffrey M. Hollomon et al. mSphere 2016; doi:10.1128/mSphere.00283-16