Thymoglobulin® Exposure Is Influencing CD4+ Immune Reconstitution As a Predictor for Improved Overall Survival in Pediatric Haematopoietic Cell Transplantation:

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Presentation transcript:

Thymoglobulin® Exposure Is Influencing CD4+ Immune Reconstitution As a Predictor for Improved Overall Survival in Pediatric Haematopoietic Cell Transplantation: Towards Individualized Dosing Rick Admiraal, MD, Charlotte van Kesteren, PharmD, PhD, Cornelia M. Jol-van der Zijde, Arjan Lankester, MD, PhD, Marc Bierings, MD, PhD, Maarten van Tol, PhD, Catherijne AJ. Knibbe, PharmD, PhD, Robbert Bredius, MD, PhD, Jaap-Jan Boelens, MD, PhD Biology of Blood and Marrow Transplantation Volume 21, Issue 2, Pages S91-S92 (February 2015) DOI: 10.1016/j.bbmt.2014.11.111 Copyright © 2015 Terms and Conditions

Figure 1 Panel A: Post-HCT AUC of active Thymoglobulin® of patients with an unsuccessful or successful CD4+ T-cell reconstitution at day +100(0) and patients with acute GvHD grade 2-4 (I) with a logistic regression depicting the chance of successful reconstitution versus post-HCT AUC (solid line) and the chance of developing aGvHD grade 2-4 versus post-HCT AUC (dot-dashed line). Dashed line: 50% chance of event. Panel B: Kaplan Meier survival curve of overall survival according to successful CD4+ immune reconstitution. Biology of Blood and Marrow Transplantation 2015 21, S91-S92DOI: (10.1016/j.bbmt.2014.11.111) Copyright © 2015 Terms and Conditions

Figure 2 OS according to post-HCT AUC in CB recipients with benign disease (panel A) and matched BM/PBSC recipients (panel B). Biology of Blood and Marrow Transplantation 2015 21, S91-S92DOI: (10.1016/j.bbmt.2014.11.111) Copyright © 2015 Terms and Conditions

Figure 3 Acute GvHD (panel A), Chronic GvHD (panel B) and graft failure (panel C) according to pre-HCT Thymoglobulin AUC. Biology of Blood and Marrow Transplantation 2015 21, S91-S92DOI: (10.1016/j.bbmt.2014.11.111) Copyright © 2015 Terms and Conditions