Comparison of transcriptome changes in Cnot6l−/− MII eggs with other experimental data. Comparison of transcriptome changes in Cnot6l−/− MII eggs with.

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Comparison of transcriptome changes in Cnot6l−/− MII eggs with other experimental data. Comparison of transcriptome changes in Cnot6l−/− MII eggs with other experimental data. Projection of transcripts with relatively increased abundance in Cnot6l−/− MII eggs and eggs with blocked decapping (Fig 5D) onto transcriptome changes in zygotes. The plot was constructed from published data (19, 20) as in Fig 4D. The y-axis shows relative changes in total RNA-seq (i.e., RNA degradation), whereas the x-axis shows poly(A) RNA changes from poly(A) RNA-seq (i.e., RNA degradation and/or deadenylation). In red are shown transcripts with significantly higher mRNA abundance in Cnot6l−/− MII eggs. In black are shown transcripts with significantly higher mRNA abundance in MII eggs upon inhibition of decapping. In blue are shown transcripts up-regulated in both conditions. Filip Horvat et al. LSA 2018;1:e201800084 © 2018 Horvat et al.