Dissection of oligoclonality.

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Dissection of oligoclonality. Dissection of oligoclonality. (A) Lineage composition of repertoires by abundance of RNA molecules. The 20 most abundant lineages across all visits are distinguished by color and vertical order; transcripts belonging to the less abundant lineages are represented in gray. Participants displaying oligoclonality are labeled “oligocl.”. (B) Isotype proportions (weighted by distinct sequences rather than molecular abundance) in the most abundant lineage at baseline. (C) Mutation loads in isotype-unswitched versus switched compartments of the most abundant lineage and of the rest of the repertoire. (D) Average mutation loads in IgD sequences. (E) Percentage of VDJ sequences in the IgD compartment that were not observed in the IgM compartment. Charles F. A. de Bourcy et al. PNAS 2017;114:5:1105-1110 ©2017 by National Academy of Sciences