Is the atrophic phenotype of tibiofemoral osteoarthritis associated with faster progression of disease? The MOST study M.D. Crema, D.T. Felson, A. Guermazi,

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Presentation transcript:

Is the atrophic phenotype of tibiofemoral osteoarthritis associated with faster progression of disease? The MOST study M.D. Crema, D.T. Felson, A. Guermazi, M.C. Nevitt, J. Niu, J.A. Lynch, M.D. Marra, J. Torner, C.E. Lewis, F.W. Roemer Osteoarthritis and Cartilage Volume 25, Issue 10, Pages 1647-1653 (October 2017) DOI: 10.1016/j.joca.2017.05.019 Copyright © 2017 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Flow chart of subjects included in the analysis. Osteoarthritis and Cartilage 2017 25, 1647-1653DOI: (10.1016/j.joca.2017.05.019) Copyright © 2017 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Subregional division of TF compartments using the WORMS system. The anterior and posterior horns of menisci serve as the reference for defining five TF regions in each compartment: A = anterior; C = central, P = posterior. The anterior (A) regions of the femoral condyles are part of the patellofemoral compartment. Osteoarthritis and Cartilage 2017 25, 1647-1653DOI: (10.1016/j.joca.2017.05.019) Copyright © 2017 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Example of atrophic TF OA on radiography and MRI. A. anteroposterior fixed-flexion radiograph shows marked medial JSN consistent with a grade 2 according to the OARSI atlas and grade 3 according to the Kellgren–Lawrence scale. There are no marginal osteophytes medial or laterally. According to our definition this knee qualifies as being atrophic. B. Corresponding sagittal MRI shows marked full thickness cartilage loss at the central region of the medial femur consistent with grade 5 cartilage damage according to the WORMS scale. Note degenerative maceration of the posterior horn of the medial meniscus. Osteoarthritis and Cartilage 2017 25, 1647-1653DOI: (10.1016/j.joca.2017.05.019) Copyright © 2017 Osteoarthritis Research Society International Terms and Conditions