NRP1-expressing myeloid cells contribute to adipose tissue vascularization. NRP1-expressing myeloid cells contribute to adipose tissue vascularization.

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NRP1-expressing myeloid cells contribute to adipose tissue vascularization. NRP1-expressing myeloid cells contribute to adipose tissue vascularization. (A) Angiogenesis GSEA of WT or LysM-Cre-Nrp1fl/fl peritoneal macrophages and (B) heat map (n = 2 to 3). NES, normalized enrichment score; FDR, false discovery rate. (C) Representative lectin stain of VAT in control and LysM-Cre-Nrp1fl/fl mice fed NCD for 18 weeks (age-matched controls to HFD mice) (magnification, ×30; scale bar, 50 μm) (left) and quantification of vessel length, area, and lacunarity (right) (n = 6 to 7 per group). A.U., arbitrary units. (D) Lectin stain of VAT in control or LysM-Cre-Nrp1fl/fl 18-week-old mice fed HFD for 10 weeks (magnification, ×30; scale bar, 50 μm) (left) with quantification for vessel length, area, and lacunarity (n = 6 to 11 per group). (E) Pimonidazole adduct staining of control or LysM-Cre-Nrp1fl/fl mice after 10 weeks on HFD (magnification, ×10; scale bar, 100 μm) (left) and quantification of hypoxyprobe stain (right) (n = 7 to 8). *P < 0.05, **P < 0.01, ***P < 0.001, Student’s unpaired t test. Ariel Molly Wilson et al. Sci. Immunol. 2018;3:eaan4626 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works