Susan J. Clark, Peter L. Molloy Cancer Cell

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Smoke-Induced Changes to the Epigenome Provide Fertile Ground for Oncogenic Mutation Susan J. Clark, Peter L. Molloy Cancer Cell Volume 32, Issue 3, Pages 278-280 (September 2017) DOI: 10.1016/j.ccell.2017.08.016 Copyright © 2017 Terms and Conditions

Figure 1 An Alternate Epigenetic Route to Oncogenic Transformation HBEC cells (left) immortalized with hTERT and mCdk4 are anchorage dependent and have epithelial cell morphology. The lower, genetic pathway shows sequential knockdown of p53 expression, followed by expression of mutant KRASV12 and c-MYC overexpression necessary for full transformation. The upper, epigenetic pathway shows progressive changes in response to CSC, leading to epithelial-mesenchymal transition, altered signaling pathways, and the capacity to form colonies in soft agar. Subsequent introduction of mutant KRASV12 provides full tumorigenic transformation. Cells from both pathways (right) show fibroblastic morphology and can form colonies in soft agar and tumors in immune-compromised mice. Cancer Cell 2017 32, 278-280DOI: (10.1016/j.ccell.2017.08.016) Copyright © 2017 Terms and Conditions