Analysis of the nonsynonymous to synonymous substitutions dN/dS (ω) for the 5,493 1:1 ortholog transcripts. Analysis of the nonsynonymous to synonymous.

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Analysis of the nonsynonymous to synonymous substitutions dN/dS (ω) for the 5,493 1:1 ortholog transcripts. Analysis of the nonsynonymous to synonymous substitutions dN/dS (ω) for the 5,493 1:1 ortholog transcripts. (A) Cumulative frequency distribution of dN/dS ratios for the 5,493 orthologs (1:1) and tissue-dependent clusters (2, 10, 3, and 13) (top) and MAGs and testes highly variable genes (bottom). (B) Normalised expression in the MAGs (top) and testes (bottom) against ω values of the 24 transcripts showing evidence of dN/dS > 1 genes are coloured and labelled based on their available functional annotation. (C) Correlation between expression and evolutionary rate (ω). The x-axis shows the ratio of nonsynonymous to synonymous substitutions (dN/dS or ω). The y-axis shows the relative normalised expression (FPKM+1). MAGs-enriched clusters (top), testes-enriched clusters (middle), and lineage-dependent clusters (bottom) Clusters are compared to all 1:1 orthologs, which generally follow the trend that higher ω is associated with lower gene expression. Abril Izquierdo et al. LSA 2019;2:e201800191 © 2019 Izquierdo et al.