Innate alloresponse is determined by a single Mendelian locus in the donor not linked to the Mhc. Innate alloresponse is determined by a single Mendelian.

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Donor SIRPα binding to recipient CD47 is required for triggering the innate alloresponse. Donor SIRPα binding to recipient CD47 is required for triggering.

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Innate alloresponse is determined by a single Mendelian locus in the donor not linked to the Mhc. Innate alloresponse is determined by a single Mendelian locus in the donor not linked to the Mhc. Bone marrow plugs were transplanted individually under the kidney capsules of separate mice. All recipients were BRG except in (D) where they were CRG. Donor strains are shown on the x axis. Recipient mono-DCs in grafts were measured as in Fig. 1. (A) Responses of BRG recipients to grafts from parental NRG and BRG strains or to grafts from (BRG × NRG)F1 and F2 generations. All donors and recipients were on the Rag2−/−γc−/− background. (B) Effect of donor-recipient non-MHC mismatch (BALB.B grafts) or MHC mismatch (B6.C grafts) on the innate alloresponse of BRG recipients. (C) Effects of donor MHC I deficiency (NOD.scid.b2m−/− grafts) on the innate alloresponse of BRG recipients. (D) Effect of MHC II deficiency (B6.MHCII−/− grafts) on the innate alloresponse of CRG recipients. n = 5 to 6 mice per group per experiment, except in F2 experiment (n = 30 mice transplanted in two separate batches). Experiments were performed once or twice. Each dot represents an individual biological replicate. Bars are means. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 (unpaired two-tailed t test). Hehua Dai et al. Sci. Immunol. 2017;2:eaam6202 Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.