CKL family is involved in the circadian clock.

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CKL family is involved in the circadian clock. CKL family is involved in the circadian clock. (A) Relative CKL and MLK expression in cells transfected with CKL-RNAi-1 compared with control cells (mean ± SEM, n = 3). Dots are mean values from three independent biological replicates. Asterisks indicate significant differences between control and CKL-RNAi-1 (Student’s t test P < 0.01, Left). (B) CCA1:LUC reporter activity codelivered with the CKL-RNAi-1 construct. Representative traces (Left), period lengths from three trials with Student’s t test P (Right). (C) Effect of a potent CK1 inhibitor PF-670462 on CKL4 and CKL1 kinase activity in vitro. Arrowheads indicate phosphorylated GST-fused CKL proteins, and asterisks show phosphorylated casein. (D) Effect of PF-670462 on period length of CCA1:LUC with one-way ANOVA P. Takahiro N. Uehara et al. PNAS 2019;116:23:11528-11536 ©2019 by National Academy of Sciences