Steven J. Harper, Charles R.V. Tomson, David O. Bates 

Slides:



Advertisements
Similar presentations
Volume 65, Issue 6, Pages (June 2004)
Advertisements

Volume 54, Issue 2, Pages (August 1998)
Volume 59, Issue 3, Pages (March 2001)
Plasma sodium and hypertension
Linear and logistic regression analysis
Volume 70, Issue 3, Pages (August 2006)
Anemia management in chronic kidney disease
Diffuse vascular calcification in a dialysis patient
Prehypertension and chronic kidney disease: the ox or the plow?
Reassessment of the care of the patient with chronic kidney disease
John P. Middleton, Patrick H. Pun  Kidney International 
Volume 63, Issue 6, Pages (June 2003)
The myogenic response in uremic hypertension
Volume 54, Issue 2, Pages (August 1998)
Interstitial fluid homeostasis and pressure: news from the black box
Yasuhiro Hamada, Masafumi Fukagawa  Kidney International 
Volume 77, Issue 8, Pages (April 2010)
Peripheral microvascular parameters in the nephrotic syndrome
George A. Kaysen, Burl R. Don
Urinary aquaporin-2 in healthy humans and patients with liver cirrhosis and chronic heart failure during baseline conditions and after acute water load 
Proinflammatory effects of iron sucrose in chronic kidney disease
Volume 74, Issue 3, Pages (August 2008)
Volume 70, Issue 11, Pages (December 2006)
Measuring transport of water across the peritoneal membrane
The epidemiology of chronic kidney disease
Effects of selectin–sialyl Lewisx blockade on mesenteric microvascular permeability associated with cardiopulmonary bypass  Charles S. Cox, MD, Steven.
Volume 87, Issue 2, Pages (February 2015)
Dedicated outpatient vascular access center decreases hospitalization and missed outpatient dialysis treatments  R. Mishler, J.J. Sands, N.J. Ofsthun,
Relationship between methylmalonic acid and cobalamin in uremia
Blood pressure targets in hemodialysis patients
Volume 65, Issue 6, Pages (June 2004)
Structure, not just function
A physician's perseverance uncovers problems in a key nephrology study
Endothelial permeability in uremia
Volume 69, Issue 12, Pages (June 2006)
Volume 69, Issue 3, Pages (February 2006)
Methods for guideline development
Cardiovascular disease in pediatric chronic dialysis patients
Volume 67, Issue 4, Pages (April 2005)
Starting dialysis is dangerous: how do we balance the risk?
Volume 65, Issue 3, Pages (March 2004)
Determinants of glomerular hypofiltration in aging humans
Douglas G Matsell, Colin T White  Kidney International 
Kathy E. Sietsema, Antonino Amato, Sharon G. Adler, Eric P. Brass 
Wei-Teing Chen, Horng-Chin Yan, Fu-Chiu Yu  Kidney International 
Phosphate binders on iron basis: A new perspective?
Organ transplantation goes to the movies
Volume 64, Issue 3, Pages (September 2003)
Volume 72, Issue 2, Pages (July 2007)
Volume 80, Issue 10, Pages (November 2011)
Volume 83, Issue 4, Pages (April 2013)
Cellular contributions to glomerular size-selectivity
Volume 80, Issue 10, Pages (November 2011)
Is it the low-protein diet or simply the salt restriction?
Volume 70, Issue 7, Pages (October 2006)
Charles A. Herzog  Kidney International 
Rita Di Leo, Giuseppe Vita, Corrado Messina, Vincenzo Savica 
Volume 71, Issue 9, Pages (May 2007)
Advisory about gadolinium calls for caution in the treatment of uremic patients with lanthanum carbonate  S. Aime, C. Canavese, P. Stratta  Kidney International 
Volume 70, Issue 5, Pages (September 2006)
Erratum Kidney International Volume 61, Issue 4, (April 2002)
Volume 54, Issue 4, Pages (October 1998)
Volume 59, Issue 3, Pages (March 2001)
The International Pediatric Peritonitis Registry: Starting to walk
Volume 74, Issue 10, Pages (November 2008)
Structural remodeling of resistance arteries in uremic hypertension
Kidney and hypertension
Vascular calcification: Not so crystal clear
Peter Stenvinkel, Olof Heimbürger, Catherine H. Tuck, Lars Berglund 
Plasma concentration and urinary excretion of N-terminal proatrial natriuretic peptides in patients with kidney diseases  Martina Franz, Wolfgang Woloszczuk,
Presentation transcript:

Human uremic plasma increases microvascular permeability to water and proteins in vivo  Steven J. Harper, Charles R.V. Tomson, David O. Bates  Kidney International  Volume 61, Issue 4, Pages 1416-1422 (April 2002) DOI: 10.1046/j.1523-1755.2002.00252.x Copyright © 2002 International Society of Nephrology Terms and Conditions

Figure 1 Effect of normal plasma on the capillary filtration rate. Filtration rate data per unit area (Jv/A) of a single perfused capillary during perfusion of normal plasma are from two different subjects. Measurements were made at two different pressures, 40 cm H2O (▪) and 30 cm H2O (•). No increase in permeability was detected. Kidney International 2002 61, 1416-1422DOI: (10.1046/j.1523-1755.2002.00252.x) Copyright © 2002 International Society of Nephrology Terms and Conditions

Figure 2 (A) Effect of uremic plasma on the capillary filtration rate. Filtration rate data per unit area (Jv/A) of a single perfused capillary during perfusion of plasma are from one healthy subject followed by plasma from a patient with chronic uremia. Measurements were made at 50 cm H2O (□), 45 cm H2O (○), 40 cm H2O (▪), 35 cm H2O (♦), 30 cm H2O (•), 25 cm H2O (▵) and 10 cm H2O (▴). The hydraulic conductivity (Lp) appeared to increase and σ appeared to decrease, consistent with a significant increase in vascular permeability. (B) Effect of uremic plasma on hydraulic conductivity. Perfusion of a vessel with uremic plasma increased Lp of a single perfused mesenteric capillary. Kidney International 2002 61, 1416-1422DOI: (10.1046/j.1523-1755.2002.00252.x) Copyright © 2002 International Society of Nephrology Terms and Conditions

Figure 3 Effect of uremic plasma on oncotic reflection coefficient. Perfusion of a vessel with uremic plasma decreased the σ of a single perfused mesenteric capillary. Kidney International 2002 61, 1416-1422DOI: (10.1046/j.1523-1755.2002.00252.x) Copyright © 2002 International Society of Nephrology Terms and Conditions

Figure 4 (A) Hydraulic conductivity (Lp) of frog mesenteric microvessels. Vessels were perfused with 5% human serum albumin (HSA), normal plasma or uremic plasma. Permeability was significantly greater during perfusion with uremic plasma than with normal plasma or HSA. (B) Reflection coefficient (σ) of frog mesenteric microvessels. Vessels were perfused with 5% HSA, normal plasma or uremic plasma. σ was significantly lower, and therefore permeability was significantly greater during perfusion with uremic plasma than with normal plasma or HSA. Data are mean ± SEM. Kidney International 2002 61, 1416-1422DOI: (10.1046/j.1523-1755.2002.00252.x) Copyright © 2002 International Society of Nephrology Terms and Conditions

Kidney International 2002 61, 1416-1422DOI: (10. 1046/j. 1523-1755 Kidney International 2002 61, 1416-1422DOI: (10.1046/j.1523-1755.2002.00252.x) Copyright © 2002 International Society of Nephrology Terms and Conditions

Kidney International 2002 61, 1416-1422DOI: (10. 1046/j. 1523-1755 Kidney International 2002 61, 1416-1422DOI: (10.1046/j.1523-1755.2002.00252.x) Copyright © 2002 International Society of Nephrology Terms and Conditions

Kidney International 2002 61, 1416-1422DOI: (10. 1046/j. 1523-1755 Kidney International 2002 61, 1416-1422DOI: (10.1046/j.1523-1755.2002.00252.x) Copyright © 2002 International Society of Nephrology Terms and Conditions

Kidney International 2002 61, 1416-1422DOI: (10. 1046/j. 1523-1755 Kidney International 2002 61, 1416-1422DOI: (10.1046/j.1523-1755.2002.00252.x) Copyright © 2002 International Society of Nephrology Terms and Conditions

Kidney International 2002 61, 1416-1422DOI: (10. 1046/j. 1523-1755 Kidney International 2002 61, 1416-1422DOI: (10.1046/j.1523-1755.2002.00252.x) Copyright © 2002 International Society of Nephrology Terms and Conditions