Human uremic plasma increases microvascular permeability to water and proteins in vivo Steven J. Harper, Charles R.V. Tomson, David O. Bates Kidney International Volume 61, Issue 4, Pages 1416-1422 (April 2002) DOI: 10.1046/j.1523-1755.2002.00252.x Copyright © 2002 International Society of Nephrology Terms and Conditions
Figure 1 Effect of normal plasma on the capillary filtration rate. Filtration rate data per unit area (Jv/A) of a single perfused capillary during perfusion of normal plasma are from two different subjects. Measurements were made at two different pressures, 40 cm H2O (▪) and 30 cm H2O (•). No increase in permeability was detected. Kidney International 2002 61, 1416-1422DOI: (10.1046/j.1523-1755.2002.00252.x) Copyright © 2002 International Society of Nephrology Terms and Conditions
Figure 2 (A) Effect of uremic plasma on the capillary filtration rate. Filtration rate data per unit area (Jv/A) of a single perfused capillary during perfusion of plasma are from one healthy subject followed by plasma from a patient with chronic uremia. Measurements were made at 50 cm H2O (□), 45 cm H2O (○), 40 cm H2O (▪), 35 cm H2O (♦), 30 cm H2O (•), 25 cm H2O (▵) and 10 cm H2O (▴). The hydraulic conductivity (Lp) appeared to increase and σ appeared to decrease, consistent with a significant increase in vascular permeability. (B) Effect of uremic plasma on hydraulic conductivity. Perfusion of a vessel with uremic plasma increased Lp of a single perfused mesenteric capillary. Kidney International 2002 61, 1416-1422DOI: (10.1046/j.1523-1755.2002.00252.x) Copyright © 2002 International Society of Nephrology Terms and Conditions
Figure 3 Effect of uremic plasma on oncotic reflection coefficient. Perfusion of a vessel with uremic plasma decreased the σ of a single perfused mesenteric capillary. Kidney International 2002 61, 1416-1422DOI: (10.1046/j.1523-1755.2002.00252.x) Copyright © 2002 International Society of Nephrology Terms and Conditions
Figure 4 (A) Hydraulic conductivity (Lp) of frog mesenteric microvessels. Vessels were perfused with 5% human serum albumin (HSA), normal plasma or uremic plasma. Permeability was significantly greater during perfusion with uremic plasma than with normal plasma or HSA. (B) Reflection coefficient (σ) of frog mesenteric microvessels. Vessels were perfused with 5% HSA, normal plasma or uremic plasma. σ was significantly lower, and therefore permeability was significantly greater during perfusion with uremic plasma than with normal plasma or HSA. Data are mean ± SEM. Kidney International 2002 61, 1416-1422DOI: (10.1046/j.1523-1755.2002.00252.x) Copyright © 2002 International Society of Nephrology Terms and Conditions
Kidney International 2002 61, 1416-1422DOI: (10. 1046/j. 1523-1755 Kidney International 2002 61, 1416-1422DOI: (10.1046/j.1523-1755.2002.00252.x) Copyright © 2002 International Society of Nephrology Terms and Conditions
Kidney International 2002 61, 1416-1422DOI: (10. 1046/j. 1523-1755 Kidney International 2002 61, 1416-1422DOI: (10.1046/j.1523-1755.2002.00252.x) Copyright © 2002 International Society of Nephrology Terms and Conditions
Kidney International 2002 61, 1416-1422DOI: (10. 1046/j. 1523-1755 Kidney International 2002 61, 1416-1422DOI: (10.1046/j.1523-1755.2002.00252.x) Copyright © 2002 International Society of Nephrology Terms and Conditions
Kidney International 2002 61, 1416-1422DOI: (10. 1046/j. 1523-1755 Kidney International 2002 61, 1416-1422DOI: (10.1046/j.1523-1755.2002.00252.x) Copyright © 2002 International Society of Nephrology Terms and Conditions
Kidney International 2002 61, 1416-1422DOI: (10. 1046/j. 1523-1755 Kidney International 2002 61, 1416-1422DOI: (10.1046/j.1523-1755.2002.00252.x) Copyright © 2002 International Society of Nephrology Terms and Conditions