Nitric Oxide Dose Response During Moderate and Severe Hypoxia in Swine

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Nitric Oxide Dose Response During Moderate and Severe Hypoxia in Swine Sherif G.S Emil, MD, Joel E Berkeland, RRT, James B Atkinson, MD The Annals of Thoracic Surgery Volume 63, Issue 2, Pages 414-418 (February 1997) DOI: 10.1016/S0003-4975(96)00835-1

Fig. 1 Mean pulmonary artery pressure (MPAP; mean ± standard error of the mean) at each intervention in the severe and moderate hypoxia groups. A dose response exists in both groups, but the curve is much steeper in the severe hypoxia group, where the highest inhaled nitric oxide (NO) dose (80 ppm) is required to return the pulmonary artery pressure to baseline. (∗p < 0.05 compared with the same intervention in the moderate hypoxia group.) The Annals of Thoracic Surgery 1997 63, 414-418DOI: (10.1016/S0003-4975(96)00835-1)

Fig. 2 Inhaled nitric oxide dose response displayed as percent change in mean pulmonary artery pressure (mean ± standard error of the mean) at each dose in the severe and moderate hypoxia groups. There is less dilation at each dose in the severe versus the moderate group. (∗p < 0.05 compared with the same dose in the severe hypoxia group.) The Annals of Thoracic Surgery 1997 63, 414-418DOI: (10.1016/S0003-4975(96)00835-1)

Fig. 3 Inhaled nitric oxide dose response displayed as percent change in pulmonary vascular resistance (mean ± standard error of the mean) at doses of 5, 20, and 80 ppm in the severe and moderate hypoxia groups. There is less resolution in elevated pulmonary vascular resistance at each dose in the severe versus the moderate group. (∗p < 0.05 compared with the same dose in the severe hypoxia group.) The Annals of Thoracic Surgery 1997 63, 414-418DOI: (10.1016/S0003-4975(96)00835-1)