Fig. 7 Transient immunosuppression (4 weeks) supports long-term graft survival and is associated with progressive decrease in spinal regional inflammatory.

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Fig. 7 Transient immunosuppression (4 weeks) supports long-term graft survival and is associated with progressive decrease in spinal regional inflammatory response in iPSC-NPC–grafted spinally injured allogeneic pig. Transient immunosuppression (4 weeks) supports long-term graft survival and is associated with progressive decrease in spinal regional inflammatory response in iPSC-NPC–grafted spinally injured allogeneic pig. (A to C) Immunofluorescence staining for MHC-II and EGFP around cell injection needle tract in syngeneic pigs (A; n = 3) and in allogeneic continuously immunosuppressed (B; n = 3) or transiently immunosuppressed (C; n = 3) spinally injured pigs 4 weeks or 3.5 months after cell grafting. (D to F) Immunofluorescence staining for Iba1 and EGFP around cell injection needle tract in syngeneic pigs (D) and in allogeneic continuously immunosuppressed (E) or transiently immunosuppressed (F) spinally injured pigs 4 weeks or 3.5 months after cell grafting. (G to I) Immunofluorescence staining for CD45, CD8, and EGFP around cell injection needle tract in syngeneic pigs (G) and in allogeneic continuously immunosuppressed (H) or transiently immunosuppressed (I) spinally injured pigs 4 weeks or 3.5 months after cell grafting. (J) Colocalization of MHC-II with Iba1 in the core of the graft. (K and L) Quantitative analysis of CD45+ and CD8+ leukocytes in EGFP+ grafts and in surrounding host tissue (Student’s t test; ***P < 0.05). Scale bars, 300 μm (A to C and G to I), 20 μm (D to F), and 10 μm (J). Jan Strnadel et al., Sci Transl Med 2018;10:eaam6651 Published by AAAS