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Volume 63, Issue 6, Pages 2302-2308 (June 2003) Hypertension increases expression of growth factors and MHC II in chronic allograft nephropathy Ralf Schindler, Stefan G. Tullius, Yakup Tanriver, Kerstin Noack, Ye Qun, Jan-Steffen Jürgensen, Ulrich Frei Kidney International Volume 63, Issue 6, Pages 2302-2308 (June 2003) DOI: 10.1046/j.1523-1755.2003.00034.x Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 1 Immunohistologic detection of proliferating cell nuclear antigen (PCNA) 3 months after renal transplantation (A). The number of PCNA-positive cells/high-power field (HPF) are shown in (B) (mean±SEM). Abbreviations are: Iso, isograft; Allo, allograft; Tx, transplantation. *P < 0.05. Kidney International 2003 63, 2302-2308DOI: (10.1046/j.1523-1755.2003.00034.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 2 Immunohistologic detection (A) and mRNA expression [reverse transcription-polymerase chain reaction (RT-PCR)] (B) of major histocompatibility complex (MHC) II 3 months after renal transplantation. The numbers indicate the ratio MHC:glyceraldehyde-3-phosphate dehydrogenase (GAPDH) determined by densitometry compared to isografts (Iso) (1.0). Abbreviations are: Allo, allograft; Tx, transplantation. Kidney International 2003 63, 2302-2308DOI: (10.1046/j.1523-1755.2003.00034.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 3 mRNA expression determined by reverse transcription-polymerase chain reaction (RT-PCR) of growth factors and collagen IV at 3 and 6 months after renal transplantation. The numbers indicate the ratio growth factor-collagen:glyceraldehyde-3-phosphate dehydrogenase (GAPDH) determined by densitometry compared to isografts (Iso) (1.0). Abbreviations are: Allo, allograft; Tx, transplantation; PDGF-B, platelet-derived growth factor-B; TGF-β; transforming growth factor-β; VEGF, vascular endothelial growth factor. Kidney International 2003 63, 2302-2308DOI: (10.1046/j.1523-1755.2003.00034.x) Copyright © 2003 International Society of Nephrology Terms and Conditions