Pericytes promote epidermal regeneration in OCs that most closely resembles human skin epidermis. Pericytes promote epidermal regeneration in OCs that.

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Pericytes promote epidermal regeneration in OCs that most closely resembles human skin epidermis. Pericytes promote epidermal regeneration in OCs that most closely resembles human skin epidermis. (A, C, E, G, H) Human keratinocytes placed in OCs with DEs made up of fibroblasts, pericytes, or a combination of both exhibited differences in morphology. Hematoxylin and eosin staining revealed a polarized basal layer (A) and immunostaining showed increased expression of the proliferative markers Ki67 (C), ΔN-p63 (E), basal layer K15 expression (G), and ordered suprabasal K10 expression (H) in the presence of pericytes. Images representative of four independent OC experiments. (B, D, F) Quantitation of increased thickness of the epithelium (B), increased number of Ki67+ cells (12 random fields/group) (D), and % basal/total ΔN-p63+ (24 random fields/group) (F) in the presence of pericytes from four independent OC experiments. Error bars are mean ± SD. Unpaired t test. **P < 0.01, ***P < 0.001, n.s. not significant. Scale bar = 100 μm. Lizhe Zhuang et al. LSA 2018;1:e201700009 © 2018 Zhuang et al.