Volume 68, Issue 3, Pages (September 2005)

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Volume 68, Issue 3, Pages 1078-1085 (September 2005) Fibroblast-specific protein 1 is a specific prognostic marker for renal survival in patients with IgAN1 Yoshiharu Nishitani, Masayuki Iwano, Yukinari Yamaguchi, Koji Harada, Kimihiko Nakatani, Yasuhiro Akai, Toshihiko Nishino, Hideo Shiiki, Masao Kanauchi, Yoshihiko Saito, Eric G. Neilson Kidney International Volume 68, Issue 3, Pages 1078-1085 (September 2005) DOI: 10.1111/j.1523-1755.2005.00500.x Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 1 Localization and Western blotting of fibroblast-specific protein 1. (A) Western blotting. FSP1 was detected in TIB 87 (fibroblast cell line) and primary human dermal fibroblast, but not in epidermal keratinocytes, smooth muscle cells, vascular endothelial cells, mesangial cells, tubular epithelial cells, and CD45+ cells. (B) Localization of FSP1. FSP1+ cells accumulate in renal areas showing interstitial fibrosis. Some tubular epithelial cells surrounding the fibrotic areas also expressed FSP1 (arrows). The control section shows very little background staining. (C) The colocalization of α-smooth muscle actin (α-SMA) with FSP1. Double-stained cells (arrows) were less than 10%. (D) FSP1 and heat shock protein 47 (HSP47) staining. Double staining of areas of active kidney fibrosis reveal that FSP1 colocalized with HSP47 in most fibroblasts, suggesting most of these cells express collagen type I. Kidney International 2005 68, 1078-1085DOI: (10.1111/j.1523-1755.2005.00500.x) Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 2 Kaplan-Meier analysis of cumulative rates of renal survival stratified into two groups on the basis of the number of fibroblast-specific protein 1 (FSP1+) fibroblasts. Renal survival estimated on the basis of an increase in serum creatinine to >100% above baseline levels. Increased numbers of FSP1+ fibroblasts were associated with diminished renal survival (P < 0.0001) among those patients whose initial serum creatinines were normal. Kidney International 2005 68, 1078-1085DOI: (10.1111/j.1523-1755.2005.00500.x) Copyright © 2005 International Society of Nephrology Terms and Conditions