Endothelin antagonists in renal disease

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Endothelin antagonists in renal disease Dr Ariela Benigni Kidney International Volume 57, Issue 4, Pages 1778-1794 (April 2000) DOI: 10.1046/j.1523-1755.2000.00023.x Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 1 (A) Time course of urinary protein excretion in rats with renal mass reduction (RMR; •) and sham-operated controls (○). Urinary protein excretion progressively rose with time in RMR rats (▴P < 0.01 vs. day 7). At 30 (°P < 0.05) and 120 days (*P < 0.01), proteinuria was significantly higher in RMR rats than in sham controls. (B) Renal endothelin-1 (ET-1) mRNA expression in RMR and sham-operated animals after surgery. (C) Corresponding densitometry of the autoradiograph shown in panel B. The optical density of the autoradiographic signals was quantitated and calculated as the ratio of prepro ET-1 to GAPDH mRNA. The transcripts of RMR kidneys were calculated relative to the mRNA levels of sham kidneys of the corresponding time. Kidney International 2000 57, 1778-1794DOI: (10.1046/j.1523-1755.2000.00023.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 2 (A) Monitoring of renal plasma flow in renal transplant patients given 5 mg/kg cyclosporine A (CsA). (B) Urinary excretion of ET-1 in renal transplant patients whose renal function is reported in panel A. Urines were collected before (basal) and after (0–6 h and 6–12 h) administration of 5 mg/kg CsA. *P < 0.01 vs. basal and 6–12 h. Kidney International 2000 57, 1778-1794DOI: (10.1046/j.1523-1755.2000.00023.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 3 (A) Representative pictures of ET-1 in situ hybridization in the kidney from a patient with CsA toxicity (left) and from a patient with chronic graft rejection (right). Intense staining was found in tubuli (magnification ×360) from patients with CsA toxicity. (B) Frequency of positive tubular staining for ET-1 in the kidney allograft biopsies from patients with CsA toxicity, chronic graft rejection, and no lesions at light microscopic evaluation. Positivity was considered when score staining intensity was ≥1 in two or more tubuli. The ratio on top of each column represents positive staining/total biopsies analyzed. Kidney International 2000 57, 1778-1794DOI: (10.1046/j.1523-1755.2000.00023.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Kidney International 2000 57, 1778-1794DOI: (10. 1046/j. 1523-1755 Kidney International 2000 57, 1778-1794DOI: (10.1046/j.1523-1755.2000.00023.x) Copyright © 2000 International Society of Nephrology Terms and Conditions